DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4aa1 and Cyp313b1

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	133/515 - (25%)
Similarity:	237/515 - (46%)	Gaps:	42/515 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLG-NCMLVTDKDLMRRCAGKAFD 78
            |.||::...:.|:...|..:...|.:   ::.:|.||...|.:| ...::..:..::...|.:..
  Fly     2 LASIILSGWLLLAWLYFLWSRRRYYK---VAWQLRGPIGWPLIGMGLQMMNPETFLQYMDGLSRQ 63

  Fly    79 LYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHNFLGDGLITSSGSKWSNHRRL 143
            .....:. |:....|..:.:|..::.||:|...|||..|||.|.:.:||||.|||..:|..||||
  Fly    64 FKAPFIS-WMGTSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLFTSSSPRWHKHRRL 127

  Fly   144 IQPAFHHNLLEKFIDTFVDASQSLYENLDAEAV--GTEINIAKYVNNCVLDILNEAVLGVPIKKR 206
            |.|||...:|..|:..|...::.|.:.|:.|.|  |..:.|.:.:...||:...:..:|   ||.
  Fly   128 INPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAACQTTMG---KKM 189

  Fly   207 G--QDVAMMEDSPFRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQK--KRLNDFTRKMIQR- 266
            .  .|.::.....:.....:...|...|||..|.||..:.:.  .|.||  ..|..|..::::.
  Fly   190 NFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLF--RLQQKVVGILFGFIEQLLEPI 252

  Fly   267 RRQIQNNNNGNSER---------KCLLDHMIEISESNRDFTEEDIVNEACTFMLAGQDSVGAAVA 322
            ...:..|:|.:.:|         |.:....:.........:.:|:.:||...:.|..::...|:.
  Fly   253 VSVVAANSNPDQQRSEMEMRGKSKAIFIEQVREHVERGQLSWQDVRDEANVTIAATFETTSTALY 317

  Fly   323 FTLFLLTQNPECQDRCVLELATIFEDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGE 387
            ||:..|..:|..|::...||.|....|... .:..|..:.|.||.|.||:||:..||::.|...:
  Fly   318 FTILCLAMHPCYQEKLHKELVTELPPSGDI-NLEQLQRLEYTEMVINEAMRLFAPVPMVLRSADQ 381

  Fly   388 EVRL----AKHTLPAGSNVFICPYATHRLAHIY-PDPEKFQPERFSPENSENRHPYAFLPFSAGP 447
            :::|    .:..:|.|:.:.|..|...|...:: |....:.|:.....:|..||.:||:||:.|.
  Fly   382 DIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQRHAFAFVPFTKGL 446

  Fly   448 RYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLKERDHPL 507
            |.|||.|:|.|.:|.:::|:.|||::      :|.|....:.::.:    :.||.:|:||
  Fly   447 RMCIGYRYAQMLMKLLLARIFRSYRI------STEARLEELLVKGN----ISLKLKDYPL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	119/446 (27%)
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	119/453 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1194
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	6	5.970