Protein Alignment Cyp4aa1 and CYP4F3

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 160/534 - (29%)
• Similarity: 261/534 - (48%)
• Gaps: 87/534 - (16%)

  Fly    19 LILLVISLS---------IYTFYATLNTYLRSVLLSLRLTGPPSLP----FLGNCMLVTDKD--- 67
            |:||::..|         .||||..          ..||...|..|    |||:..|:...:
Human    20 LLLLLVGASWLLARILAWTYTFYDN----------CCRLRCFPQPPKRNWFLGHLGLIHSSEEGL 74

  Fly    68 LMRRCAGKAF-DL-------YGSLVRIW-------VLLFPFFAVLEPEDLQVILSSKKHTNKVFF 117
            |..:.....| |:       :.::|||:       ||..|  |.:.|:|            || |
Human    75 LYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAP--AAIVPKD------------KV-F 124

  Fly   118 YRLMHNFLGDGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTF---VDASQSLYENLDAEAVGTE 179
            |..:..:|||||:.|:|.|||.|||::.||||.|:|:.::..|   |:...:.::.|.:|. ...
Human   125 YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEG-SAR 188

  Fly   180 INIAKYVNNCVLDILNEAVLGVPI----KKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLLDGIY 240
            :::.::::...||.|.:.|.....    |......|::|.|      .::..|..|..|.:|.:|
Human   189 LDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELS------ALVTKRHQQILLYIDFLY 247

  Fly   241 HWTKMANDELNQKKRLNDFTRKMIQRRRQ------IQNNNNGNSERKCL--LD-HMIEISESNRD 296
            :.|..........:.::|||..:||.||:      :.:.....::.|.|  :| .::...|..:.
Human   248 YLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKK 312

  Fly   297 FTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP---TMTDL 358
            .::|||..||.|||..|.|:..:.:::.|:.|.::||.|:||..|:..:.:|  |.|   ...||
Human   313 LSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKD--REPKEIEWDDL 375

  Fly   359 HEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDPEKF 422
            .::.::.|||||:|||:|.||.::|...:::.|.. ..:|.|....|..:.||....::||||.:
Human   376 AQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVY 440

  Fly   423 QPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFR 487
            .|.||.|:|.:.|.|.||:|||||||.|||..||:.|:|.::...|..:::||  ..|.......
Human   441 DPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLP--DHTEPRRKPE 503

  Fly   488 ITLRASGGLWVRLK 501
            :.|||.||||:|::
Human   504 LVLRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	139/443 (31%)
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	143/466 (31%)