DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp4d8

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	155/524 - (29%)
Similarity:	268/524 - (51%)	Gaps:	57/524 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ILILLVISLSIYTFYATLNTYL------RSVLLSLRLTGPPSLPFLGNCML---VTDKDLMRRCA 73
            :|.|||:.|    |.|....:|      |.|   ..|.||...|.:|...|   :..|..::  .
  Fly     2 LLFLLVVLL----FGAGWIIHLGQADRRRKV---ANLPGPICPPLIGAMQLMLRLNPKTFIK--V 57

  Fly    74 GKAFDL-YGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHNFLGDGLITSSGSKW 137
            |:.:.| :|.|.|:|:.........:.|..:.:|||::|..|...|:::..:||:||:.|.|..|
  Fly    58 GREYVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNGLLLSDGKVW 122

  Fly   138 SNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVGTEINIAKYVNNCVLDILNEAVLGVP 202
            ...|::|.|.||.::||:|::.|...|....:.|..:|.|...::.:.:....|||:.|..:|..
  Fly   123 HQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSICAAALDIIAETAMGTK 187

  Fly   203 IKKRGQDVAMMEDSPFRQG----KIMMPARFTQPWLLLDGIYHWT----KMANDELNQKKRLNDF 259
            |..:..     |.:|:.:.    ..::..||...:|.::.::..|    |....:|  .:.:.:|
  Fly   188 IYAQAN-----ESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQL--IRTMQEF 245

  Fly   260 TRKMIQRRRQIQNNNN-----------GNSERKCLLDHMIEISESNRDFTEEDIVNEACTFMLAG 313
            |.|:|::|||...:..           |:..|..|||.::..:...|..|.::|..|..|||..|
  Fly   246 TIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVDTFMFEG 310

  Fly   314 QDSVGAAVAFTLFLLTQNPECQDRCVLELATIF-EDSNRAPTMTDLHEMRYMEMCIKEALRLYPS 377
            .|:..:|::|.|..|:::||.|.:.:.|:..:. .|.:|..::.||.|::|||..|||:||:||.
  Fly   311 HDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPP 375

  Fly   378 VPLIARKLGEEVRLAKHT------LPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRH 436
            ||::.|||..:.:.. |:      :||||.:.|..:..||....:|:|::|.|||.  ||.....
  Fly   376 VPIVGRKLQTDFKYT-HSVHGDGVIPAGSEIIIGIFGVHRQPETFPNPDEFIPERH--ENGSRVA 437

  Fly   437 PYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLK 501
            |:..:|||||||.|||.:||.:|:|.::::::|.|:|||:..:  :.....|.||:..|..:.::
  Fly   438 PFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQR--VECIVNIVLRSETGFQLGMR 500

  Fly   502 ERDH 505
            :|.|
  Fly   501 KRKH 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	136/454 (30%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	134/442 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460469
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.900