DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp46a1

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_006240610.1	Gene:	Cyp46a1 / 362782	RGDID:	1306605	Length:	500	Species:	Rattus norvegicus

Alignment Length:	459	Identity:	122/459 - (26%)
Similarity:	207/459 - (45%)	Gaps:	58/459 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LTGPPSLPF-LGNCMLVTDKDLMRRCAGKAFDL-------YGSLVRIWVLLFPFFAVLEPEDLQV 104
            :.|||...| ||:......||  ..|.....|:       ||.:||:.|.......|..||.::.
  Rat    33 IPGPPRPSFLLGHLPYFWKKD--EACGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKK 95

  Fly   105 ILSSKKHTNKVFFYRLMHNFLGD-----GLITSSG-SKWSNHRRLIQPAFHHNLLEKFIDTFVDA 163
            .|.|.|:......||.:....|:     ||::... .:|...||::..||..:.|...:.||.:.
  Rat    96 FLMSTKYNKDSKMYRAIQTVFGERLFGQGLVSECDYGRWYKQRRVMDLAFSRSSLVSLMGTFNEK 160

  Fly   164 SQSLYENLDAEAVG-TEINIAKYVNNCVLDILNEAVLGVPIKKRGQDVAMM--EDSPFRQG-KIM 224
            ::.|.|.|:|:|.| |.:::...:....:|||.:|..|:       :.:|:  ...|..|. |:|
  Rat   161 AEQLMEILEAKADGQTPVSMQDMLTCATIDILAKAAFGM-------ETSMLLGAQKPLSQAVKVM 218

  Fly   225 MPARFTQPWLLLDGI-YHWTKMANDELNQKKRLNDFTRKM----------IQRRRQIQNNNNGNS 278
                       |:|| .....:|.....::|:|.:....:          :||||:..  ..|..
  Rat   219 -----------LEGISASRNTLAKFMPGKRKQLREIRESIRLLRQVGKDWVQRRREAL--KRGED 270

  Fly   279 ERKCLLDHMIEISESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELA 343
            ....:|..:::..|..:|  :|.:::...||.:||.::....:|||:..|::.||...|...|:.
  Rat   271 VPADILTQILKAEEGAQD--DEVLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVD 333

  Fly   344 TIFEDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYA 408
            .:. .|.|.....||..::|:...:||:|||||......|.|.||..:....:|..:.:....|.
  Rat   334 EVV-GSKRHLDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYV 397

  Fly   409 THRLAHIYPDPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLR--SY 471
            ..|:...:.||..|.|:||.|...:.|  :.:.|||.|.|.|||.:||.||:|.::::||:  .:
  Rat   398 MGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 460

  Fly   472 QLLP 475
            :|:|
  Rat   461 RLVP 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	121/455 (27%)
Cyp46a1	XP_006240610.1	p450	34..466	CDD:278495	122/458 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810