DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp4p2

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	133/535 - (24%)
Similarity:	239/535 - (44%)	Gaps:	64/535 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPF------------LGNCMLVTDKD 67
            :|.:.|.:.|.:.|:..|.....|......:.|:......|.            ..||..:..||
  Fly     3 ICLLWISVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLGKD 67

  Fly    68 L------MRRCAGKAFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHNFLG 126
            .      :|:.|..:.|.|..    :.:.|..|.|::..:...||:......|...|..:|.||.
  Fly    68 TDQVFTHLRQLAKNSGDSYLQ----YSMGFSNFNVIDAHNAANILNHPNLITKGVIYNFLHPFLR 128

  Fly   127 DGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDAS---QSLYENLDAEAVGTEINIAKYVNN 188
            .|::|::..||...|.::...||.::|.:|.:.|:..|   .|.::..:...|..:..|:::..|
  Fly   129 TGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQFQGQNEVVVSLKDRISRFTLN 193

  Fly   189 CVLDILNEAVLGVPIKKRGQDVAMMEDSPFR-------QGKIMMPARFTQPWLLLDGIYHWTKMA 246
            .:.    |..:|:.:.:..:     :...:|       :|   :..|...|....|.:|:  ...
  Fly   194 SIC----ETAMGIKLDEMAE-----KGDRYRANFHIIDEG---LTRRIVNPLYWDDCVYN--MFT 244

  Fly   247 NDELNQK-KRLNDFTRKMIQRRR-----QIQNNNNGNS----------ERKCLLDHMIEISESNR 295
            ..:.|.. |.:::|:|::|.:||     :::|.....:          :|..:||.:| .:|.:.
  Fly   245 GHKYNAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLI-CAEKDG 308

  Fly   296 DFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMTDLHE 360
            ...:..|..|..|.|..|.|:....:.|.|..::.....|:.|..|:.....|......::.|.:
  Fly   309 LIDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNLNLSQLSK 373

  Fly   361 MRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKH-TLPAGSNVFICPYATHRLAHIYPDPEKFQP 424
            :.|:...|||.:|||||:|::.|:..:|..|... .||..|.:.|..:..||....:..||:|:|
  Fly   374 LNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPEEFRP 438

  Fly   425 ERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRIT 489
            |||.|:|...|||||::|||||.|.|||.::|:.|:||::..:|:.:::|||....:|.....||
  Fly   439 ERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVIDPKSIVFQVGIT 503

  Fly   490 LRASGGLWVRLKERD 504
            ||....:.|:|..|:
  Fly   504 LRFKNKIKVKLVRRN 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	115/469 (25%)
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	121/469 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460493
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.000