DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp4ad1

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	139/503 - (27%)
Similarity:	233/503 - (46%)	Gaps:	68/503 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LTGPPSLPFLGNCM------LVTDKDLMRRCAGKAFDLYGSLVRIWVLLFPFFAVLEPEDLQVIL 106
            :.||...||:||..      ....|.:::.|  :.:|..|  .|..|.|.....:.:|.::|.||
  Fly    35 IPGPTPYPFVGNLFQFGLKPAEYPKKVLQYC--RKYDFQG--FRSLVFLQYHMMLSDPAEIQNIL 95

  Fly   107 SSKKHTNKVFFYRLMHNFLGDGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENL 171
            ||.....|...|..:..:|||||:||||::|..|::|..|||..:.:|.::...........:.|
  Fly    96 SSSSLLYKEHLYSFLRPWLGDGLLTSSGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKL 160

  Fly   172 DAEAVGTEI-NIAKYVNNCVLDILNEAVLGVPIKKRGQDVAMM--EDSPF-----------RQGK 222
            |..:...|: :..:.|..|.|||:.|       ...|||.:.:  |.|..           ::..
  Fly   161 DVLSDTQEVFDAQELVAKCTLDIVCE-------NATGQDSSSLNGETSDLHGAIKDLCDVVQERT 218

  Fly   223 IMMPARFTQPWLLLDGIYHWTKMANDELNQKKRL----NDFTRKMIQRRRQIQNNN---NGNSER 280
            ..:..||       |.::   ::.:..:.|::.|    ::..|.:.|||.|:...|   .|....
  Fly   219 FSIVKRF-------DALF---RLTSYYMKQRRALSLLRSELNRIISQRRHQLAAENTCQQGQPIN 273

  Fly   281 KCLLDHMIEISESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATI 345
            |..||.::......:...|.:|:.|..||:..|.|.:.||::|||:.|:::.|.|.:...|...|
  Fly   274 KPFLDVLLTAKLDGKVLKEREIIEEVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRI 338

  Fly   346 F-EDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYAT 409
            | |:......:..|.:|.|:|:.|:|.||||||||||||.....:.:....:...:.|.:|..|.
  Fly   339 FGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAM 403

  Fly   410 HRLAHIYPDPEKFQPERF-SPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQL 473
            ......:.||..|:|||| :|..:.....:..:|||||||.||..:||:.::|.::|:|||.:::
  Fly   404 GYNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEI 468

  Fly   474 LPVT------------------GKTTIAATFRITLRASGGLWVRLKER 503
            ||..                  .:.......|:||::..|:.:||::|
  Fly   469 LPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKSENGIQIRLRKR 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	130/453 (29%)
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	130/454 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460471
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.900