Protein Alignment Cyp4aa1 and CYP26C1

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_899230.2
• Gene: CYP26C1 / 340665
• HGNCID: 20577
• Length: 522
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 114/536 - (21%)
• Similarity: 187/536 - (34%)
• Gaps: 156/536 - (29%)

  Fly    15 LCSILILLVISLSIYTFYATLNTYL---RSVLLSLRLTGPPSLPFLGNCM--LVTDKDLMRRCAG 74
            ||:.|:|   ||:.:.:  ||...|   |:..|.|. .|....||.|..:  ||         .|
Human    20 LCAGLLL---SLAQHLW--TLRWMLSRDRASTLPLP-KGSMGWPFFGETLHWLV---------QG 69

  Fly    75 KAF-----DLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHNFLGD-GLITSS 133
            ..|     :.||::.:..:|..|...|...|:::.||..:....:..:.:..|..||. .|:.:.
Human    70 SRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAV 134

  Fly   134 GSKWSNHRRLIQPAFHHNLLEKFID--------------------TFVDASQSLYENLDAE-AVG 177
            |......|:::...|....||:::.                    :..|||::|...:.|. .:|
Human   135 GEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDASKALTFRMAARILLG 199

  Fly   178 TEINIAKYVNNC-----VLDILNEAVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLLD 237
            ..::.|:    |     ..:.|.|.:..:|:           |.||                  .
Human   200 LRLDEAQ----CATLARTFEQLVENLFSLPL-----------DVPF------------------S 231

  Fly   238 GIYHWTKMANDELNQKKRLNDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIE-------ISESNR 295
            |:                     ||.|:.|.|:..:..|....|...|...|       |..|.|
Human   232 GL---------------------RKGIRARDQLHRHLEGAISEKLHEDKAAEPGDALDLIIHSAR 275

  Fly   296 DFTEEDIVNE----ACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFED-------- 348
            :...|..:.|    |...:.|...:..:|....:.||.|:|..       :|.|.|:
Human   276 ELGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQHPAA-------IAKIREELVAQGLGR 333

  Fly   349 -----------SNRAP---------TMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAK 393
                       |...|         ::..|..:||::..:||.|||.|.|....|.......|..
Human   334 ACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDG 398

  Fly   394 HTLPAGSNVFICPYATHRLAHIY-PDPEKFQPERFSPENSENR---HPYAFLPFSAGPRYCIGNR 454
            :.:|.|.:|......||..|.:| ..||.|.||||.....::|   ..:.::||..|.|.|:|..
Human   399 YQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQE 463

  Fly   455 FAIMEIKTIVSRLLRS 470
            .|...::.:...|:|:
Human   464 LAQAVLQLLAVELVRT 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	93/460 (20%)
CYP26C1	NP_899230.2	CYP26C1	59..508	CDD:410729	99/491 (20%)