DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp4d21

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	149/518 - (28%)
Similarity:	274/518 - (52%)	Gaps:	47/518 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ILLVISLSIYTF-------YATLNTYLRSVLLSLRLTGPPSLPFLGN---CMLVTDKDLMRRCAG 74
            |||.|::.|.|.       ...:||:.:|     |:.||.::|.:||   .:.:..::.::| .|
  Fly     3 ILLGIAVLIMTLVWDNSRKQWRVNTFEKS-----RILGPFTIPIVGNGLQALTLRPENFIQR-FG 61

  Fly    75 KAFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHNFLGDGLITSSGSKWSN 139
            ..|:.||...|:|:|........:.:..:.||||.....|...||.:.:||||||:.|:|:||::
  Fly    62 DYFNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLSTGNKWTS 126

  Fly   140 HRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVG-TEINIAKYVNNCVLDILNEAVLGVPI 203
            .|:::.||||...||.|::.....|..:.|.|...|.| |.:::.|:|:...||:..|..:||.:
  Fly   127 RRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAMGVQV 191

  Fly   204 KKRGQD----VAMMEDSPFRQGKIMMPARFTQPWLL-LDGIYHWTKMANDELNQKKRLNDFTRKM 263
            ..:.:.    ...::...:.:.|.:........||. |.....:.::..|    ...:.|||.|:
  Fly   192 NAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKD----IAIMQDFTDKV 252

  Fly   264 IQRRRQI---------------QNNNNGNSERKCLLDHMIEISESNRDFTEEDIVNEACTFMLAG 313
            |:.||.|               .:::.|...:..|||.:::.:..|:..::.||..|...|:.||
  Fly   253 IRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNKPLSDVDIREEVDVFIFAG 317

  Fly   314 QDSVGAAVAFTLFLLTQNPECQDRCVLE--LATIFEDSNRAPTMTDLHEMRYMEMCIKEALRLYP 376
            .|:..:.|:..|..::::|:.|: |:.|  ::.:..|.:.:.|.|.|.|::|::..|||.:||:|
  Fly   318 DDTTTSGVSHALHAISRHPKVQE-CIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRLHP 381

  Fly   377 SVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERF-SPENSENRHPYAF 440
            .||::.|.:.|::::.:.|:|..:::.:.||..:|....:|||..|:|||: ..:.:.|..|.|:
  Fly   382 PVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTPPLAY 446

  Fly   441 LPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLKER 503
            :|||:||:.|||.:||.:::|.::|:::|.|:|||:  ...:.||:...|.:|.|..|.||.|
  Fly   447 IPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPL--GADLKATYTFILSSSTGNNVGLKPR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	128/451 (28%)
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	129/452 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460470
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	7.990