DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp26c1

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_217935.3	Gene:	Cyp26c1 / 308190	RGDID:	1308843	Length:	518	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	118/551 - (21%)
Similarity:	206/551 - (37%)	Gaps:	121/551 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNCM--LVTDKDLMRRCAGKAF 77
            ||:.| ||.::..::|...||:....|.|...:  |....||.|..:  ||         .|..|
  Rat    20 LCAGL-LLGLAQQLWTLRWTLSRDWASTLPLPK--GSMGWPFFGETLHWLV---------QGSRF 72

  Fly    78 -----DLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHNFLGD-GLITSSGSK 136
                 :.||::.:..:|..|...|...|:::.||..:....:..:.:..|..||. .|:.:.|.:
  Rat    73 HSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGER 137

  Fly   137 WSNHRRLIQPAFHHNLLEKFIDTFVDASQ-------------SLYENLDAEA--------VGTEI 180
            ....|:::...|....||:|:....:|.:             ::|:...|..        :|.::
  Rat   138 HRQRRKVLARVFSRPALEQFVPRLQEALRREVRSWCAAQRPVAVYQAAKALTFRMAARILLGLQL 202

  Fly   181 NIAKYVNNC-----VLDILNEAVLGVPIKKRGQDVAMMEDSPF---RQGKIMMPARFTQPWLLLD 237
            :.|:    |     ..:.|.|.:..:|:           |.||   |:|   :.||        |
  Rat   203 DEAR----CTELAQTFERLVENLFSLPL-----------DVPFSGLRKG---IRAR--------D 241

  Fly   238 GIYHWTKMANDELNQKKRLNDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEISESNRDFTEEDI 302
            .:|...    ||:..:|...:.|.:.......|.|:                ..|..|:.:.:::
  Rat   242 QLYQHL----DEVIAEKLREELTAEPGDALHLIINS----------------ARELGRELSVQEL 286

  Fly   303 VNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELAT--IFEDSNRAP------------ 353
            ...|...:.|...:..:|....:.||.|:|....:...||:.  :....:.||
  Rat   287 KELAVELLFAAFFTTASASTSLILLLLQHPAAIAKIQQELSAQGLGSPCSCAPRASGSRPDCSCE 351

  Fly   354 ---TMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHI 415
               ::..|..:||::..:||.|||.|.|....|.......|..:.:|.|.:|......||..|.:
  Rat   352 PDLSLAVLGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAV 416

  Fly   416 Y-PDPEKFQPERFSPENSENRHP---YAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPV 476
            | ..||.|.||||..|:.:.|..   :.::||..|.|.|:|...|...::.:...|:|:.:....
  Rat   417 YRSPPEGFDPERFGVESEDARGSGGRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWELA 481

  Fly   477 TGKTTIAATFRITLRASGGLWVRLKERDHPL 507
            |....:..|..|.....|.|.:     .|||
  Rat   482 TPAFPVMQTVPIVHPVDGLLLL-----FHPL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	100/482 (21%)
Cyp26c1	XP_217935.3	p450	40..500	CDD:299894	105/516 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910