DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	146/523 - (27%)
Similarity:	251/523 - (47%)	Gaps:	38/523 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LERTT-NLELCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLP----FLGNCMLVTDK 66
            ||:|. .:.:.|.|:|.::.|...........:....:...||:..|..|    .||:..:....
  Rat    14 LEKTAFRVYVLSALLLFLLFLLFRLLLQAFKLFSDFRITCRRLSCFPEPPGRHWLLGHMSMYLPN 78

  Fly    67 DLMRRCAGKAFDLYGSLVRIWVLLF-PFFAVLEPEDLQVIL--SSKKHTNKVFFYRLMHNFLGDG 128
            :...:...|..|....::..||..| |...::.|:.::.:|  |:.......|||..:..:||||
  Rat    79 EKGLQNEKKVLDTMHHIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKPWLGDG 143

  Fly   129 LITSSGSKWSNHRRLIQPAFHHNLLEKFIDTF---VDASQSLYENLDAEAVGTEINIAKYVNNCV 190
            |:.|.|:|||.||||:.||||.::|:.::..|   |:...:.:....||...|..::.::|:...
  Rat   144 LLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQSVNIMHAKWRRHLAEGSVTSFDMFEHVSLMT 208

  Fly   191 LDILNEAVLGV--PIKKRGQDV--AMMEDSPF---RQGKIMMPARFTQPWLLLDGIYHWTKMAND 248
            ||.|.:.|...  ..:::..|.  :::|.|..   ||.::..         .||.||:.|.....
  Rat   209 LDSLQKCVFSYSSDCQEKLSDYISSIIELSALVVRRQYRLHH---------YLDFIYYLTADGRR 264

  Fly   249 ELNQKKRLNDFTRKMIQRRRQIQNNNNGNSERKC----LLDH----MIEISESNRDFTEEDIVNE 305
            .......:::||.::||:||:........:..|.    .||.    ::...|..::.::|||..|
  Rat   265 FRQACDTVHNFTTEVIQQRRRALRELGAEAWLKAKQGKTLDFIDVLLLAKDEEGKELSDEDIRAE 329

  Fly   306 ACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSN-RAPTMTDLHEMRYMEMCIK 369
            |.|||..|.|:..:.:::.||.|.:.||.||:|..|:..:.:... ......||.::.:..||||
  Rat   330 ADTFMFEGHDTTSSGLSWALFNLAKYPEYQDKCREEIQEVMKGRELEELDWDDLTQLPFTTMCIK 394

  Fly   370 EALRLYPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSE 433
            |:||.:|.|.||:|:..|:::|.. ..:|.|....:..|.||....::||.:.:.|.||.|:..:
  Rat   395 ESLRQFPPVTLISRRCTEDIKLPDGRIIPKGIICLVSIYGTHYNPLVWPDSKVYNPYRFDPDIPQ 459

  Fly   434 NRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWV 498
            .|.|.||:|||||||.|||..||:.|::.:|:..|..:: |.|.....:.....:.||...|||:
  Rat   460 QRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFR-LSVDRTRKVRRKPELILRTENGLWL 523

  Fly   499 RLK 501
            .::
  Rat   524 NVE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	130/451 (29%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	132/450 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348369
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750