DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001028858.2	Gene:	Cyp4f18 / 290623	RGDID:	1305261	Length:	524	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	158/530 - (29%)
Similarity:	257/530 - (48%)	Gaps:	67/530 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LILLVISLSIYTFYATLNTY--------LRSVLLSLRLTGPPSLPFL-GNCMLVTDKD---LMRR 71
            |:||::..|....|.....|        ||      |...||:..:| |:..|:...:   |..:
  Rat    20 LLLLLVGASCLLAYILPQVYAVFENSRRLR------RFPQPPTRNWLFGHLGLIQSSEEGLLYIQ 78

  Fly    72 CAGKAF-DLYGSLVRIWVLLFPFFAVLEPEDLQVIL---SSKKHTNKVFFYRLMHNFLGDGLITS 132
            ...:.| |:....|..|   .|...:..|..::.::   :|....::| |||.:..:|||||:.|
  Rat    79 SLSRTFRDVCCWWVGPW---HPVIRIFHPAFIKPVILAPASVAPKDRV-FYRFLKPWLGDGLLLS 139

  Fly   133 SGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLD--AEAVGTEINIAKYVNNCVLDILN 195
            :|.|||.||.::.||||.|:|:.::..|.|::..::....  |......:::.::::...||.|.
  Rat   140 TGDKWSRHRHMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLASQGSARLDMFEHISLMTLDSLQ 204

  Fly   196 EAVLGVPI----KKRGQDVAMMEDSPFRQGKIMMPARFTQPWLL-LDGIYHWTKMANDELNQKKR 255
            :.|.....    |......|::|.|       .:.||..|..|| :|..||.|:   |.:..:|.
  Rat   205 KCVFSFDSNCQEKPSEYITAILELS-------ALVARRHQSLLLYVDLFYHLTR---DGMRFRKA 259

  Fly   256 ---LNDFTRKMIQRRRQIQNNNNGNSERKC-----LLDH----MIEISESNRDFTEEDIVNEACT 308
               ::|||..:|:.||:...:..|:...|.     .||.    ::...|.....::|||..||.|
  Rat   260 CRLVHDFTDAVIRERRRTLPDQGGDDALKAKAKAKTLDFIDVLLLSKDEHGEALSDEDIRAEADT 324

  Fly   309 FMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP---TMTDLHEMRYMEMCIKE 370
            ||..|.|:..:.:::.|:.|.::||.|:||..|:..:..|  |.|   ...||.::.::.|||||
  Rat   325 FMFGGHDTTASGLSWILYNLAKHPEYQERCRQEVRELLRD--REPEEIEWDDLAQLPFLTMCIKE 387

  Fly   371 ALRLYPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSEN 434
            :|||:|....|:|...:::.|.. ..:|.|....|..:.||....::||||.:.|.||..:|.|.
  Rat   388 SLRLHPPATAISRCCTQDIMLPDGRVIPKGVICRISIFGTHHNPAVWPDPEVYNPFRFDADNGEG 452

  Fly   435 RHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVR 499
            |.|.||:|||||||.|||..||:.|:|..::..|..:::||...:.....  .:.|||.||||:|
  Rat   453 RSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPDDKEPRRKP--ELILRAEGGLWLR 515

  Fly   500 LKERDHPLIA 509
            ::    ||.|
  Rat   516 VE----PLSA 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	136/455 (30%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	140/458 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348453
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750