Protein Alignment Cyp4aa1 and CYP4A22

DIOPT Version :9

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 146/544 - (26%)
• Similarity: 252/544 - (46%)
• Gaps: 100/544 - (18%)

  Fly    13 LELCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNCM-LVTDKDLMR------ 70
            |::.|:||||::.:.....|......|:::   .:...|||....|:.. ...|::|.|
Human    19 LQVTSLLILLLLLIKAAQLYLHRQWLLKAL---QQFPCPPSHWLFGHIQEFQHDQELQRIQERVK 80

  Fly    71 ----RCAGKAFDLYGSLVRIWVLLFPFFAVLEPEDLQVIL---SSKKHTNKVFFYRLMHNFLGDG 128
                .|   .:.::|..||:        .:.:|:.::|||   ..|.|.:    |:.:...:|.|
Human    81 TFPSAC---PYWIWGGKVRV--------QLYDPDYMKVILGRSDPKSHGS----YKFLAPRIGYG 130

  Fly   129 LITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVGTE--INIAKYVNNCVL 191
            |:..:|..|..|||::.||||:::|:.::....|:.:.:.:..: |.:|.:  :.:.::|:...|
Human   131 LLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWE-ELLGQDSPLEVFQHVSLMTL 194

  Fly   192 DILNEAVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLL-------------------D 237
            |                  .:|:.:...||.|.:. |.:|.::..                   |
Human   195 D------------------TIMKSAFSHQGSIQVD-RNSQSYIQAISDLNSLVFCCMRNAFHEND 240

  Fly   238 GIY------HWTKMANDELNQKKRLNDFTRKMIQ-RRRQIQNNNNGNSE---RKCLLDH----MI 288
            .||      .||..|....:|      .|.::|| |:.|:|  ..|..|   ||..||.    ::
Human   241 TIYSLTSAGRWTHRACQLAHQ------HTDQVIQLRKAQLQ--KEGELEKIKRKRHLDFLDILLL 297

  Fly   289 EISESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP 353
            ...|:....:::|:..|..|||..|.|:..:.:::.|:.|..:|:.|:||..|:..:..| ..:.
Human   298 AKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGD-GASI 361

  Fly   354 TMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYP 417
            |...|.:|.|..|||||||||||.||.|.|:|...|.... .:||.|..|.:..|..|....::|
Human   362 TWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWP 426

  Fly   418 DPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTI 482
            :.|.|.|.||:|.:::  |.:||||||.|.|.|||.:||:.::|...:..|..::|||...:..|
Human   427 NLEVFDPSRFAPGSAQ--HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPI 489

  Fly   483 AATFRITLRASGGLWVRLKERDHP 506
            ... |:.|::..|:.:||:...:|
Human   490 PMA-RLVLKSKNGIHLRLRRLPNP 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	129/474 (27%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	135/499 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154679
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740