DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4aa1 and Cyp4a12a

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_803125.2	Gene:	Cyp4a12a / 277753	MGIID:	88612	Length:	508	Species:	Mus musculus

Alignment Length:	521	Identity:	157/521 - (30%)
Similarity:	259/521 - (49%)	Gaps:	64/521 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LELCSILILLVISLSIYTFYATLNTYL-RSVLLS--LRLTGPPSLPFLGNCMLVTD--KDLMRRC 72
            |::.|:|.||::      .:.|...|| |..|||  .:...|||....|:.:|...  :|::.|.
Mouse    19 LQVASVLSLLLL------LFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTRI 77

  Fly    73 AGKAFD------LYGSLVRIWVLLFPFFAVLEPEDLQVIL--SSKKHTNKVFFYRLMHNFLGDGL 129
              |.|.      |:||.|||        .|.:|:.:::||  |..|....   ||.:..::|.||
Mouse    78 --KNFPSACPQWLWGSKVRI--------QVYDPDYMKLILGRSDPKANGS---YRFLAPWIGRGL 129

  Fly   130 ITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVGTE--INIAKYVNNCVLD 192
            :...|..|..|||::.||||:::|:.:.:...|:.:.:.:..: :.||.:  :.|.:::....||
Mouse   130 LMLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVRVMLDKWE-QIVGQDSTLEIFRHITLMTLD 193

  Fly   193 ILNEAV--------LGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLLDGIYHWTKMANDE 249
            .:.:..        |....|...|.|..:.|..|.:.:.:    |.|.    |.||..:......
Mouse   194 TIMKCAFSHEGSVQLDRKYKSYIQAVEDLNDLVFSRVRNI----FHQN----DIIYRVSSNGCKA 250

  Fly   250 LNQKKRLNDFTRKMIQRRR-QIQNNNN-GNSERKCLLDHMIEI-----SESNRDFTEEDIVNEAC 307
            .:..|..:|.|.::|:.|| |:|:... ...::|..|| .::|     .|:.:..:::|:..|..
Mouse   251 NSACKLAHDHTDQVIKSRRIQLQDEEELEKLKKKRRLD-FLDILLFARMENGKSLSDKDLRAEVD 314

  Fly   308 TFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMTDLHEMRYMEMCIKEAL 372
            |||..|.|:..:.:::..:.|..|||.|.||..|:.::..|.. :.|..||.:|.|..|||||||
Mouse   315 TFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGT-SITWNDLDKMPYTTMCIKEAL 378

  Fly   373 RLYPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRH 436
            |:||.||.::|:|...|.... .:||.|.:|.:..|..|....::|:||.|.|.||:|.:|  ||
Mouse   379 RIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSS--RH 441

  Fly   437 PYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLK 501
            .::|||||.|.|.|||.:||:.|:|..|:..|..::|||...:..|... ||.|::..|:.:.||
Mouse   442 SHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIP-RIVLKSKNGIHLHLK 505

  Fly   502 E 502
            :
Mouse   506 K 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	136/452 (30%)
Cyp4a12a	NP_803125.2	p450	52..502	CDD:278495	143/476 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750