DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	160/530 - (30%)
Similarity:	266/530 - (50%)	Gaps:	65/530 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLP--FLGNCMLV-TDKDLMRRCA--GKAF-D 78
            ||..|...|||||..        ...||....|..|  |.|:..|: .:::.|:..|  |:.| |
  Rat    31 ILARILAWIYTFYDN--------CCRLRCFPQPPKPSWFWGHLTLMKNNEEGMQFIAHLGRNFRD 87

  Fly    79 LYGSLVRIWV-LLFPFFAVLEPEDLQVIL--SSKKHTNKVFFYRLMHNFLGDGLITSSGSKWSNH 140
            ::.|    || .::|...::.|..:..:|  |:.....::..|..:..:|||||:.|:|.||::|
  Rat    88 IHLS----WVGPVYPILRLVHPNVIAPLLQASAAVAPKEMTLYGFLKPWLGDGLLMSAGEKWNHH 148

  Fly   141 RRLIQPAFHHNLLEKFIDTF---VDASQSLYENLDAEAVGTEINIAKYVNNCVLDILNEAVLGVP 202
            |||:.||||.::|:.::..|   |:...:.::.|.|:. ...:::.::::...||.|.:.:....
  Rat   149 RRLLTPAFHFDILKSYVKIFNKSVNTMHAKWQRLTAKG-SARLDMFEHISLMTLDSLQKCIFSFD 212

  Fly   203 IKKRGQD----VAMMEDSPFRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQKKR---LNDFT 260
            ...:..:    .|::|.|.      ::..|..||:|.||.:|:.|.   |....:|.   :::||
  Rat   213 SNCQESNSEYIAAILELSS------LIVKRQRQPFLYLDFLYYLTA---DGRRFRKACDVVHNFT 268

  Fly   261 RKMIQRRRQIQNNNNGNSERKC-----LLDH----MIEISESNRDFTEEDIVNEACTFMLAGQDS 316
            ..:|:.||...|....:...|.     .||.    ::...|..:..::.||..||.|||..|.|:
  Rat   269 DAVIRERRSTLNTQGVDEFLKARAKTKTLDFIDVLLLAKDEHGKGLSDVDIRAEADTFMFGGHDT 333

  Fly   317 VGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP---TMTDLHEMRYMEMCIKEALRLYPSV 378
            ..:|:::.|:.|.::||.|:||..|:..:..|  |.|   ...||.::.::.|||||:|||:|.|
  Rat   334 TASALSWILYNLARHPEYQERCRQEVRELLRD--REPEEIEWDDLAQLPFLTMCIKESLRLHPPV 396

  Fly   379 PLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPYAFLP 442
            .||:|...:::.|.. ..:|.|:...|..:..|....::||||.:.|.||.|||.:.|.|.||:|
  Rat   397 LLISRCCSQDIVLPDGRVIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPENPQKRSPLAFIP 461

  Fly   443 FSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLK------ 501
            ||||||.|||..||:.|||..::..|..:.:||...:.....  .:.|||.||||:|::
  Rat   462 FSAGPRNCIGQTFAMSEIKVALALTLLRFCVLPDDKEPRRKP--ELILRAEGGLWLRVEPLSTVT 524

  Fly   502 -ERDHPLIAH 510
             :....|:||
  Rat   525 SQLPWDLLAH 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	137/456 (30%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	145/479 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348439
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750