Protein Alignment Cyp4aa1 and CYP4X1

DIOPT Version :9

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 490
• Identity: 147/490 - (30%)
• Similarity: 244/490 - (49%)
• Gaps: 36/490 - (7%)

  Fly    35 LNTYLR--SVLLSLR-LTGPPSLPFLGNCMLVTDKDLMRRCAGKAFDLYGSLVRIWVLLF-PFFA 95
            :..|||  .:|..|| ...||:..|||:...:.|.::.:  ..:..:.|......|:..| .||.
Human    30 IKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEK--LEEIIEKYPRAFPFWIGPFQAFFC 92

  Fly    96 VLEPEDLQVILSSKKHTNKVFFYRLMHNFLGDGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTF 160
            :.:|:..:.:| |:......:..:.....||.||....|.||..||||:.|.||.|:|:.:|:..
Human    93 IYDPDYAKTLL-SRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVM 156

  Fly   161 VDASQSLYENLD--AEAVGTEINIAKYVNNCVLDILNEAVLGVPIKKRGQDVAMMED----SPFR 219
            ..:.:.:.:..:  .....|.:.:.:::|:..|||:.:....   |:.........|    :.|.
Human   157 AHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFS---KETNCQTNSTHDPYAKAIFE 218

  Fly   220 QGKIMMPARFTQPWLLL---DGIYHWTKMANDELNQKKRLNDFTRKMIQRRRQ-----IQNNNNG 276
            ..||:    |.:.:.||   |.|:..:..........:.||.:|..:||.|::     ::.:|..
Human   219 LSKII----FHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTP 279

  Fly   277 NSERKCLLDHMIEI-SESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVL 340
            ..:.:..||.::.. .||...|::.|:.:|..||:|||.|::.|::::.|:.|..|||.|:||..
Human   280 KRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCRE 344

  Fly   341 ELATIFEDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKH-TLPAGSNVFI 404
            |:..|..|.: :.|...|.||.|..|||||..||.|:||.|:|.|.:.:..... |||||..|.:
Human   345 EVRGILGDGS-SITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVL 408

  Fly   405 CPYATHRLAHIYPDPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLR 469
            ..:..|....::.:|:.|.|.|||.|||:.|||||:||||||.|.|||..||::|:|..::.:|.
Human   409 SIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILL 473

  Fly   470 SYQLLPVTGKTTIAATF--RITLRASGGLWVRLKE 502
            .::   ||...|...||  ...|:...|:::.||:
Human   474 HFR---VTPDPTRPLTFPNHFILKPKNGMYLHLKK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	132/441 (30%)
CYP4X1	NP_828847.1	p450	47..501	CDD:306555	139/467 (30%)
		heme binding region	447..460		8/12 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154669
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750