DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and erg11

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_592990.1	Gene:	erg11 / 2542599	PomBaseID:	SPAC13A11.02c	Length:	495	Species:	Schizosaccharomyces pombe

Alignment Length:	510	Identity:	109/510 - (21%)
Similarity:	185/510 - (36%)	Gaps:	108/510 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPS----LPFLGNCML--VTDKDLMRRCAGKA 76
            :.|||.|:|:.|.      .|:.:.|.|.....||.    :||:|:.:.  :......|.|..|.
pombe     6 VSILLSIALAWYV------GYIINQLTSRNSKRPPIVFHWIPFVGSAVAYGMDPYVFFRECRAKY 64

  Fly    77 FDLYGSLVRIWVLLFPFFAV-------------LEPEDLQVILSSKKHTNKVFFYRLMHNFLGDG 128
            .|:: :.|.:...:..|..|             |..|:....|::......|.:....|.|:...
pombe    65 GDVF-TFVCMGRKMTAFLGVQGNDFLFNGKLADLNAEEAYSHLTTPVFGKDVVYDIPNHVFMEHK 128

  Fly   129 LITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVGTEINIAKYVNNCVLDI 193
            ....||..:|..|..:.      |:...:|.|:..|.......:..|     ::.|.:....:..
pombe   129 KFIKSGLGFSQFRSYVP------LILNEMDAFLSTSPDFGPGKEGVA-----DLLKTMPVMTIYT 182

  Fly   194 LNEAVLGVPIKKRGQDVAMME-----DSPFRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQK 253
            .:..:.|..::| |.|....:     |..|      .|..|..|||.|               .:
pombe   183 ASRTLQGAEVRK-GFDAGFADLYHDLDQGF------SPVNFVFPWLPL---------------PR 225

  Fly   254 KRLNDFTRKMIQRR-------RQIQNNNNGNSERKCLLDHMIEISESNRDFTEEDIVNEACTFML 311
            .|..|...|::|:.       |:....|.|......|:....   ...|...|.:|.......::
pombe   226 NRRRDRAHKIMQKTYLKIIKDRRSSTENPGTDMIWTLMSCKY---RDGRPLKEHEIAGMMIALLM 287

  Fly   312 AGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP------TMTDLHEMRYMEMCIKE 370
            |||.:..|.:.:.|.||...||     ::|:  ::|:..|..      ......:|..:...|:|
pombe   288 AGQHTSAATIVWVLALLGSKPE-----IIEM--LWEEQKRVVGENLELKFDQYKDMPLLNYVIQE 345

  Fly   371 ALRLYPSVPLIARKLGEEVRL--AKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFS----- 428
            .|||:|.:....||:..::.:  :|..:||.:.:...|..|......:.....|.|:|::
pombe   346 TLRLHPPIHSHMRKVKRDLPVPGSKIVIPANNYLLAAPGLTATEEEYFTHATDFDPKRWNDRVNE 410

  Fly   429 PENSEN------------RHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSY 471
            .||:|.            ..||  |||.||...|||.:||.|.:.||:|:.:..|
pombe   411 DENAEQIDYGYGLVTKGAASPY--LPFGAGRHRCIGEQFAYMHLSTIISKFVHDY 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	100/478 (21%)
erg11	NP_592990.1	CypX	28..495	CDD:225035	100/482 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960