DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	147/525 - (28%)
Similarity:	245/525 - (46%)	Gaps:	79/525 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SILILLVISLSIYTFYATLNTYLRSVLLSLRL---TGPPSLPFLGNCMLVTDKDLMRRCAGKAFD 78
            |::||:||.|.:::.      .||...|:..:   .|||:....|:.:.:              .
  Rat    18 SVVILMVIVLKLFSL------LLRRQKLARAMDSFPGPPTHWLFGHALEI--------------Q 62

  Fly    79 LYGSLVRI--WVLLFP------------FFAVLEPEDLQVILSSKKHTNKVFFYRLMHNFLGDGL 129
            ..|||.::  |...||            |..:.||:..:.:. |:........|.....::|.||
  Rat    63 KLGSLDKVVSWAQQFPHAHPLWFGQFVGFLNIYEPDYAKAVY-SRGDPKAADVYDFFLQWIGKGL 126

  Fly   130 ITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEA-VGTEINIAKYVNNCVLDI 193
            :...|.||..||:|:.|.||:::|:.::..|.::::.:.:..:.:| .....:|...|.:..||.
  Rat   127 LVLDGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSFDIFCDVGHMALDT 191

  Fly   194 LNEAVLGVPIKKRGQDVAMMEDSPFRQG----KIMMPARFTQPWLLLDGIYHWT----------K 244
            |.:...|     :|.......|:.:...    .::|..|........|.||..|          |
  Rat   192 LMKCTFG-----KGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACK 251

  Fly   245 MANDE----LNQKKRL--NDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEI-SESNRDFTEEDI 302
            :|:|.    :.|:|..  ::..||.||:||.:.           .||.::.: .||....::.::
  Rat   252 IAHDHTDEVIRQRKAALQDEKERKKIQQRRHLD-----------FLDILLGVRDESGIKLSDAEL 305

  Fly   303 VNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMTDLHEMRYMEMC 367
            ..|..|||..|.|:..:.:::.|:.:...||.|..|..|:..|..|.: :....||.:|.|:.||
  Rat   306 RAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGDQD-SFQWDDLAKMTYLTMC 369

  Fly   368 IKEALRLYPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPEN 431
            :||..||||.||.:.|:|.:.|.... .:|||||.:.:..||.||.:.::||||.|.|.||||||
  Rat   370 MKECFRLYPPVPQVYRQLNKPVTFVDGRSLPAGSLISLHIYALHRNSTVWPDPEVFDPLRFSPEN 434

  Fly   432 SENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGL 496
            :..|||:||:|||||||.|||.:||:.|:|.:.:..|..::......|..|... ::.||:..|:
  Rat   435 AAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSLDPSKMPIKVP-QLILRSKNGI 498

  Fly   497 WVRLK 501
            .:.||
  Rat   499 HLYLK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	131/461 (28%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	136/485 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348456
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750