DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001094915.1	Gene:	Cyp4f17 / 208285	MGIID:	3646233	Length:	524	Species:	Mus musculus

Alignment Length:	515	Identity:	154/515 - (29%)
Similarity:	262/515 - (50%)	Gaps:	58/515 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LILLVISLSIYTFYATLNTYLRSVLLSLR-LTGPPSLP-FLGNCMLVTDKD----LMRRCAGKAF 77
            |.|..|...|..||   :.|.|     || ...|||.. |.|:..:|.:.:    |:...:.:..
Mouse    29 LFLARILTWICAFY---DNYCR-----LRCFPEPPSRHWFWGHMSMVKNNEEGLQLLTERSHQFH 85

  Fly    78 DLYGSLVRIWV-LLFPFFAVLEPEDLQVIL--SSKKHTNKVFFYRLMHNFLGDGLITSSGSKWSN 139
            |::    ..|: ..:|...::.|:.:..||  |:.....::.||..:..:|||||:.|:|.|||.
Mouse    86 DVH----LCWIGPFYPILRLIHPKFIGPILQASAAVAPKEMIFYGFLKPWLGDGLLVSAGEKWSR 146

  Fly   140 HRRLIQPAFHHNLLEKFIDTF---VDASQSLYENLDAEAVGTE-INIAKYVNNCVLDILNEAVLG 200
            ||.|:.||||.::|:.::..|   |:...:.::.|..:  ||. :::.::::...||.|...|..
Mouse   147 HRHLLTPAFHFDILKPYMKNFNKSVNIMHAKWQRLTTK--GTACLDMLEHISLMTLDSLQNCVFS 209

  Fly   201 VPIKKRGQDVAMMEDSP------FRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQKKRLNDF 259
            ..        :..::||      .::...::..|..||:|.||.:|:.|............:::|
Mouse   210 FD--------SNCQESPSEYIAAIQELSSLIVKRHHQPFLYLDFLYYCTADGRRFRKACDLVHNF 266

  Fly   260 TRKMIQRRRQIQNNNNGN----SERKCLLDHMIEI-----SESNRDFTEEDIVNEACTFMLAGQD 315
            |..:|:.||:..::.|.:    |:.|......|::     .|..::.::|||..||.|||..|.|
Mouse   267 TDAVIRERRRTLSSQNLDEFLKSKTKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHD 331

  Fly   316 SVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP---TMTDLHEMRYMEMCIKEALRLYPS 377
            :..:|:::.|:.|.::||.|:||..|:..:..  .|.|   ...||.::.::.|||||:|||:|.
Mouse   332 TTASALSWILYNLARHPEYQERCRQEVQELLR--GREPQEIEWDDLAQLPFLTMCIKESLRLHPP 394

  Fly   378 VPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPYAFL 441
            |.:|:|...::|.|.. ..:|.|::..|..:..|....::||||.:.|.||.|||.:.|.|.||:
Mouse   395 VTVISRCCTQDVVLPDGRVIPKGTDCVISIFGVHHNPEVWPDPEVYDPFRFDPENPQKRSPLAFI 459

  Fly   442 PFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLK 501
            |||||||.|||..||:.|:|..::..|..:::||  |.........:.|||.||||:|::
Mouse   460 PFSAGPRNCIGQTFAMREMKVALALTLLRFRVLP--GDKEPRRKPELILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	133/455 (29%)
Cyp4f17	NP_001094915.1	p450	52..515	CDD:365848	143/480 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845000
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750