Protein Alignment Cyp4aa1 and cyp-13A8

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_496115.1
• Gene: cyp-13A8 / 188358
• WormBaseID: WBGene00011674
• Length: 509
• Species: Caenorhabditis elegans
• Alignment Length: 543
• Identity: 128/543 - (23%)
• Similarity: 231/543 - (42%)
• Gaps: 93/543 - (17%)

  Fly    19 LILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNCMLVTDKDL--------MRRCAGK 75
            :|..:|.:||.|:|....|:.:    ...|.||..:|..|....:.:...        ..:..||
 Worm     1 MIFELILISIVTYYFWHWTFWK----RRGLPGPWGVPIFGKAGAMLEDSFPPGYTLQKWTKEYGK 61

  Fly    76 AFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHN-FLGD-------GLITS 132
            .:.....:.::.|       :.:|:.:|.|| .|::.|   ||...|| ..||       .::.:
 Worm    62 IYGFTEGMQKVMV-------ISDPDLVQEIL-VKQYDN---FYGRKHNPVQGDPDKDKDIHIVGA 115

  Fly   133 SGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAV-GTEINIAKYVNNCVLDILNE 196
            .|.:|...|.:..|||.:..::|.:.|..|::|.|.:.|..|:. |..:|:..:......|:::.
 Worm   116 QGFRWKRLRTITAPAFSNGSIKKVLTTMEDSTQELMKKLREESENGKAVNMHLFYQEYTFDVISR 180

  Fly   197 AVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLLDG------IYHW------------- 242
            ..:|.|      |..|.::...:..|........|.|:...|      ...|
 Worm   181 VAMGQP------DSQMFKNPLLKDVKGFFEHNRWQIWMFSGGFPFAVSFLKWLFIKVGKFGAGPF 239

  Fly   243 ------------TKMANDELNQKKRLN-----DFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEI 290
                        :::|..|.::|..:.     |:....:..|.::::....|.|     .|. ..
 Worm   240 IVVQKSVTDAVMSRIAQREADKKHGVEPGEAADYIDMFLNARAEVEHFGESNDE-----FHK-SS 298

  Fly   291 SESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTM 355
            |.:||..|.::|:::...|::||.|:...::::..:.|..||:.|.:...|:..  |..|...|.
 Worm   299 SYNNRQLTTQEIISQCFVFLVAGFDTTAISLSYVTYFLALNPKIQSKLQDEVDK--ECPNDEITF 361

  Fly   356 TDLHEMRYMEMCIKEALRLYPSVPLI-ARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIY-PD 418
            ..|.:::||:..|||:|||:|..... :|:......:.:..:.||.:|.|..:..|...::: .|
 Worm   362 DQLSKLKYMDNVIKESLRLFPFASFANSRRCMRNTVIGEQIVEAGVDVMIDTWTLHHDKNVWGND 426

  Fly   419 PEKFQPERF-SPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKT-- 480
            .|:|:|||: ||...:.    |:|.|.||||.|:|.|||::|.|.::|.:|:.| ......||
 Worm   427 VEEFKPERWDSPLTPQQ----AYLSFGAGPRVCLGMRFALLEQKGLLSHILKKY-TFETNAKTQL 486

  Fly   481 TIAATFRITLRASGGLWVRLKER 503
            .|....|.|.|.. .|::.||.|
 Worm   487 PIKLVGRATARPE-NLFLSLKPR 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	111/466 (24%)
cyp-13A8	NP_496115.1	CYP3A-like	58..500	CDD:410678	112/472 (24%)