Protein Alignment Cyp4aa1 and cyp-13A4

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_496111.1
• Gene: cyp-13A4 / 188355
• WormBaseID: WBGene00011671
• Length: 520
• Species: Caenorhabditis elegans
• Alignment Length: 556
• Identity: 130/556 - (23%)
• Similarity: 234/556 - (42%)
• Gaps: 119/556 - (21%)

  Fly    17 SILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNCMLVTDKD---LMRRCAGKAFD 78
            |:||...:.:...|:|    .::.|..:...:.||...||.|..:...|.:   |::  .|:...
 Worm     4 SLLIAGALFIGFLTYY----IWIWSFWIRKGVKGPRGFPFFGVILKFHDYENPGLLK--LGEWTK 62

  Fly    79 LYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVF------FY-RLMHNFLGD-------GL 129
            .|||:          :.:.|..:..:::|:.:..::||      || |..:...||       .|
 Worm    63 KYGSI----------YGITEGVEKTLVVSNPEFVHEVFVKQFDNFYGRKTNPIQGDPNKNKRAHL 117

  Fly   130 ITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLD-AEAVGTEINIAKYVNNCVLDI 193
            :.:.|.:|...|.|..|.|.:..|.|.:.|..:....|..:|| |.|.|..:::..|.....|||
 Worm   118 VLAQGHRWKRLRTLASPTFSNKSLRKIMSTVEETVVELMRHLDEASAKGKAVDLLDYYQEFTLDI 182

  Fly   194 LNEAVLGVPIKKRGQDVAMMEDSP--------FRQGKIMMPARFTQPWLLLDGIYHWTKMANDEL 250
            :....:       ||..::|..:|        |::|. .||       .|:.|::   .:|...:
 Worm   183 IGRIAM-------GQTESLMFRNPMLPKVKEIFKKGG-KMP-------FLIAGVF---PIAGTLM 229

  Fly   251 NQ------------------KKRLNDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEISESNRDF 297
            .|                  :|.||   :::.||....:.....:.|.:..:|..:: :.:|.||
 Worm   230 RQLFMKFPKFSPAFGIMNTMEKALN---KRLEQRAADKKAGIEPSGEPQDFIDLFLD-ARANVDF 290

  Fly   298 TEE---------------------DIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLE 341
            .||                     :|:.:...|:|||.|:...:::::.:||..:||.|.:...|
 Worm   291 IEEESTLGFAKSEVLKVDKHLTFDEIIGQLFVFLLAGYDTTALSLSYSSYLLATHPEIQKKLQEE 355

  Fly   342 LATIFEDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLI-ARKLGEEVRLAKHTLPAGSNVFIC 405
            :..  |..:...|...:.:::|||..:|||||:||...|: .||..::..:....:..|:||.:.
 Worm   356 VDR--ECPDPEVTFDQISKLKYMECVVKEALRMYPLASLVHNRKCMKKTNVLGVEIDEGTNVQVD 418

  Fly   406 PYATHRLAHIY-PDPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLR 469
            .:..|....:: .|..:|:|||:...:........:|||..|||.|||.|.|:||.|.:::.:|:
 Worm   419 TWTLHYDPKVWGDDASEFKPERWETGDELFYAKGGYLPFGMGPRICIGMRLAMMEEKLLLTHILK 483

  Fly   470 SYQL---------LPVTGKTTIA---ATFRITLRAS 493
            .|..         |.:.|..|||   ...::|.|.|
 Worm   484 KYTFDTSTETEIPLKLVGSATIAPRNVMLKLTPRHS 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	115/489 (24%)
cyp-13A4	NP_496111.1	CYP3A-like	63..511	CDD:410678	113/481 (23%)