Protein Alignment Cyp4aa1 and CYP51A1

DIOPT Version :9

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 118/521 - (22%)
• Similarity: 215/521 - (41%)
• Gaps: 86/521 - (16%)

  Fly     5 KVLERTTNLELCS-ILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPP----SLPFLGNCMLVT 64
            :.:|:.|...|.| :||....:||:.........:|  |.|...:..||    .:||||:.:
Human    22 QAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHL--VQLPAGVKSPPYIFSPIPFLGHAI--- 81

  Fly    65 DKDLMRRCAGK--------AFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKH---------- 111
                   ..||        |::.||.:....::...|..:|..:...::.:||..
Human    82 -------AFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSR 139

  Fly   112 -TNKVFFYRLMHN-----FLGDGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYEN 170
             |..||...:.::     ||....:..||...::.::      |.:::||          ...|.
Human   140 LTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQ------HVSIIEK----------ETKEY 188

  Fly   171 LDAEAVGTEINIAKYVNNCVLDILNEAVLGVPIKKR-GQDVAMME---DSPFRQGKIMMPARFTQ 231
            .::.....|.|:.:.::..::...:..:.|..|:.: .:.||.:.   |..|.....::|.
Human   189 FESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPG---- 249

  Fly   232 PWLLLDGIYHWTKMANDELNQKKRLNDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEIS-ESNR 295
             ||.|...     ...|..:  :.:.|...|.||:|||.|...:.      :|..:::.: :..|
Human   250 -WLPLPSF-----RRRDRAH--REIKDIFYKAIQKRRQSQEKIDD------ILQTLLDATYKDGR 300

  Fly   296 DFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMTDLHE 360
            ..|::::.......:||||.:.....|:..|.|.::...|.:|.||..|:..::....|...|.:
Human   301 PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKD 365

  Fly   361 MRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPE 425
            :..::.||||.|||.|.:.::.|.......:|.:|:|.|..|.:.|....||...:.:...|.|:
Human   366 LNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPD 430

  Fly   426 RFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQL------LPVTGKTTIAA 484
            |:..:|..:...:|::||.||...|||..||.::||||.|.:||.|:.      .|....||:..
Human   431 RYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIH 495

  Fly   485 T 485
            |
Human   496 T 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	103/463 (22%)
CYP51A1	NP_000777.1	p450	67..483	CDD:299894	103/459 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1934
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860