Protein Alignment Cyp4aa1 and CYP4A11

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 148/542 - (27%)
• Similarity: 252/542 - (46%)
• Gaps: 96/542 - (17%)

  Fly    13 LELCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNCM-LVTDKDLMRRCAGKA 76
            |:..|:||||::.:.....|......|:::   .:...|||....|:.. |..|::|.|
Human    19 LQAASLLILLLLLIKAVQLYLHRQWLLKAL---QQFPCPPSHWLFGHIQELQQDQELQR------ 74

  Fly    77 FDLYGSLVRIWVLLFPF------------FAVLEPEDLQVIL---SSKKHTNKVFFYRLMHNFLG 126
                   ::.||..||.            ..:.:|:.::|||   ..|.|.:    ||.:..::|
Human    75 -------IQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGS----YRFLAPWIG 128

  Fly   127 DGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVGTE--INIAKYVNNC 189
            .||:..:|..|..|||::.||||:::|:.::....|:.:.:.:..: |.:|.:  :.:.::|:..
Human   129 YGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWE-ELLGQDSPLEVFQHVSLM 192

  Fly   190 VLDILNEAVL----GVPIKKRGQD-VAMMED----------SPFRQGKIMMPARFTQPWLLLDGI 239
            .||.:.:...    .:.:.:..|. :..:.|          :.|.|.               |.|
Human   193 TLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN---------------DTI 242

  Fly   240 Y------HWTKMANDELNQKKRLNDFTRKMIQ-RRRQIQNNNNGNSE---RKCLLDH----MIEI 290
            |      .||..|....:|      .|.::|| |:.|:|  ..|..|   ||..||.    ::..
Human   243 YSLTSAGRWTHRACQLAHQ------HTDQVIQLRKAQLQ--KEGELEKIKRKRHLDFLDILLLAK 299

  Fly   291 SESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTM 355
            .|:....:::|:..|..|||..|.|:..:.:::.|:.|..:|:.|:||..|:.::..| ..:.|.
Human   300 MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGD-GASITW 363

  Fly   356 TDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDP 419
            ..|.:|.|..|||||||||||.||.|.|:|...|.... .:||.|..|.:..|..|....::|:|
Human   364 NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 428

  Fly   420 EKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAA 484
            |.|.|.||:|.:::  |.:||||||.|.|.|||.:||:.|:|...:..|..::|||...:..|..
Human   429 EVFDPFRFAPGSAQ--HSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPI 491

  Fly   485 TFRITLRASGGLWVRLKERDHP 506
            . |:.|::..|:.:||:...:|
Human   492 A-RLVLKSKNGIHLRLRRLPNP 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	129/463 (28%)
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	130/475 (27%)