Protein Alignment Cyp4aa1 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 132/514 - (25%)
• Similarity: 230/514 - (44%)
• Gaps: 61/514 - (11%)

  Fly    20 ILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNCMLVTDKDLMRRCAGKAFDL--YGS 82
            :||.:||.:...|.|..   ..:...|.:.||..||||||.       |..|.....||:  |..
Human    13 LLLAVSLILLYLYGTRT---HGLFKKLGIPGPTPLPFLGNA-------LSFRKGYWTFDMECYKK 67

  Fly    83 LVRIWVLL---FPFFAVLEPEDLQVILSSKKHTNKVFFYRLMH---NFLGDGLITSSGSKWSNHR 141
            ..::|.:.   .|..|:.:|:.::.:|  .|....||..|...   .|:.:.:..:...:|...|
Human    68 YRKVWGIYDCQQPMLAITDPDMIKTVL--VKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIR 130

  Fly   142 RLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEA-VGTEINIAKYVNNCVLDILNEAVLGVPIKK 205
            .|:.|.|....|::.:.........|..||..|| .|..:.:........:|::.....||.|
Human   131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSI-- 193

  Fly   206 RGQDVAMMEDSPFRQG--KIMMPARFT--QPWLLLDGIYHWTKMANDELNQKKRLNDFTRKMI-- 264
               |.......||.:.  |::   ||.  .|::|...::.:.....:.||    :..|.||:|
Human   194 ---DSLNNPQDPFVENTKKLL---RFNPLDPFVLSIKVFPFLTPILEALN----ITVFPRKVISF 248

  Fly   265 --QRRRQIQNN--NNGNSERKCLLDHMIEI-----SESNRDFTEEDIVNEACTFMLAGQDSVGAA 320
              :..:||:..  ......|...|..||:.     ||:::..::.:::.::..|:.||.::..:.
Human   249 LTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSV 313

  Fly   321 VAFTLFLLTQNPECQDRCVLELATIFEDSNRA-PTMTDLHEMRYMEMCIKEALRLYPSVPLIARK 384
            ::|.::.|..:|:.|.:...|:.|:.  .|:| ||...:.::.|::|.:.|.|||:|....:.|.
Human   314 LSFIIYELATHPDVQQKVQKEIDTVL--PNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERV 376

  Fly   385 LGEEVRLAKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPYAFLPFSAGPRY 449
            ..::|.:....:|.|..|.|..|..|.....:.:||||.|||||.:|.:|..||.:.||.:|||.
Human   377 CKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441

  Fly   450 CIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLKERDHPLI 508
            |||.|||::.:|..:.|:|:::...|.. :|.|....|.     |||.:..|    |::
Human   442 CIGMRFALVNMKLALVRVLQNFSFKPCK-ETQIPLKLRF-----GGLLLTEK----PIV 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	110/439 (25%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	112/450 (25%)