Protein Alignment Cyp4aa1 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_034140.1
• Gene: Cyp46a1 / 13116
• MGIID: 1341877
• Length: 500
• Species: Mus musculus
• Alignment Length: 459
• Identity: 121/459 - (26%)
• Similarity: 208/459 - (45%)
• Gaps: 58/459 - (12%)

  Fly    48 LTGPPSLPF-LGNCMLVTDKDLMRRCAGKAFDL-------YGSLVRIWVLLFPFFAVLEPEDLQV 104
            :.|||...| ||:......||  ..|.....|:       ||.:||:.|.......|..||.::.
Mouse    33 IPGPPRPSFLLGHLPYFWKKD--EDCGRVLQDVFLDWAKKYGPVVRVNVFYKTSVIVTSPESVKK 95

  Fly   105 ILSSKKHTNKVFFYRLMHNFLGD-----GLITSSG-SKWSNHRRLIQPAFHHNLLEKFIDTFVDA 163
            .|.|.|:......||.:....|:     ||::... .:|...|:::..||..:.|...::||.:.
Mouse    96 FLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECDYGRWYKQRKVMDLAFSRSSLVSLMETFNEK 160

  Fly   164 SQSLYENLDAEAVG-TEINIAKYVNNCVLDILNEAVLGVPIKKRGQDVAMM--EDSPFRQG-KIM 224
            ::.|.|.|:|:|.| |.:::...:....:|||.:|..|:       :.:|:  ...|..|. |:|
Mouse   161 AEQLVEILEAKADGQTPVSMQDMLTCATIDILAKAAFGM-------ETSMLLGAQKPLSQAVKVM 218

  Fly   225 MPARFTQPWLLLDGI-YHWTKMANDELNQKKRLNDFTRKM----------IQRRRQIQNNNNGNS 278
                       |:|| .....:|.....::|:|.:....:          :||||:..  ..|..
Mouse   219 -----------LEGISASRNTLAKFMPGKRKQLREIRESIRLLRQVGKDWVQRRREAL--KRGED 270

  Fly   279 ERKCLLDHMIEISESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELA 343
            ....:|..:::..|..:|  :|.:::...||.:||.::....:|||:..|::.||...|...|:.
Mouse   271 MPADILTQILKAEEGAQD--DEVLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVD 333

  Fly   344 TIFEDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYA 408
            .:. .|.|.....||..::|:...:||:|||||......|.|.||..:....:|..:.:....|.
Mouse   334 EVV-GSKRHLDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYV 397

  Fly   409 THRLAHIYPDPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLR--SY 471
            ..|:...:.||..|.|:||.|...:.|  :.:.|||.|.|.|||.:||.||:|.::::||:  .:
Mouse   398 MGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEF 460

  Fly   472 QLLP 475
            :|:|
Mouse   461 RLVP 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	110/418 (26%)
Cyp46a1	NP_034140.1	CYP46A1-like	61..484	CDD:410706	112/429 (26%)