Protein Alignment Cyp4aa1 and Cyp3a11

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_031844.1
• Gene: Cyp3a11 / 13112
• MGIID: 88609
• Length: 504
• Species: Mus musculus
• Alignment Length: 503
• Identity: 135/503 - (26%)
• Similarity: 225/503 - (44%)
• Gaps: 75/503 - (14%)

  Fly    13 LELCSIL-----ILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNCMLVTDKDLMRRC 72
            ::|.|.|     :||.|||.:...|.|..   ..:.....:.||..|||||. :|...|.|.:
Mouse     1 MDLVSALSLETWVLLAISLVLLYRYGTRK---HELFKKQGIPGPKPLPFLGT-VLNYYKGLWK-- 59

  Fly    73 AGKAFDL--YGSLVRIWVLL---FPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHNFLGDGLIT- 131
                ||:  |....:.|.|.   .|..||.:||.::.:|  .|....||..|  .:|...|:::
Mouse    60 ----FDMECYKKYGKTWGLFDGQTPLLAVTDPETIKNVL--VKECFSVFTNR--RDFGPVGIMSK 116

  Fly   132 ----SSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEA-VGTEINIAKYVNNCVL 191
                |...:|..:|.|:.|.|....|::...........|.:.|..:| .|..:.:...:....:
Mouse   117 AISISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSM 181

  Fly   192 DILNEAVLGVPIKKRGQDVAMMEDSPF-RQGKIMMPARFTQPWL-------LLDGIYHWTKMAND 248
            |::.....||.:     |.....:.|| .:.|.::...|..|.|       .|..:|   :|.|.
Mouse   182 DVITSTSFGVNV-----DSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVLFPFLTPVY---EMLNI 238

  Fly   249 ELNQKKRLNDFTRKMIQRRR---------------QIQNNNNGNSERKCLLDHMIEISESNRDFT 298
            .:..|..: :|.:|.:.|.:               |:..|::.||:.|.          |::..:
Mouse   239 CMFPKDSI-EFFKKFVDRMKESRLDSKQKHRVDFLQLMMNSHNNSKDKV----------SHKALS 292

  Fly   299 EEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRA-PTMTDLHEMR 362
            :.:|..::..|:.||.::..:.::|||..|..:|:.|.:...|:....  .|:| ||...:.||.
Mouse   293 DMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEAL--PNKAPPTYDTVMEME 355

  Fly   363 YMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERF 427
            |::|.:.|.|||||....:.|...::|.|....:|.||.|.|..||.|.....:.:||:||||||
Mouse   356 YLDMVLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERF 420

  Fly   428 SPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLP 475
            |.||..:..||.:|||..|||.|:|.|||:|.:|..::::::::...|
Mouse   421 SKENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQP 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	112/428 (26%)
Cyp3a11	NP_031844.1	CYP3A	67..493	CDD:410743	112/427 (26%)