DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp26a1

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_031837.2	Gene:	Cyp26a1 / 13082	MGIID:	1096359	Length:	497	Species:	Mus musculus

Alignment Length:	514	Identity:	118/514 - (22%)
Similarity:	207/514 - (40%)	Gaps:	94/514 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LCSI---LILLVISLSIYTFYATLNTYLRSVLLSLRLTGPP---SLPFLGNCMLVTDKDLMRRCA 73
            ||:.   |:|.:.:|.::..|. :::..||..|.|    ||   ..||.|..:.:.   |.||
Mouse    11 LCTFVLPLLLFLAALKLWDLYC-VSSRDRSCALPL----PPGTMGFPFFGETLQMV---LQRR-- 65

  Fly    74 GKAFDL----YGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHNFLGDGLITS-S 133
             |...:    ||.:.:..:...|...|:..::::.||..:.....|.:...:...||.|.::: .
Mouse    66 -KFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGAGCLSNLH 129

  Fly   134 GSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVGTEINIAKYVNNCV---LDILN 195
            .|.....:::|..||....|:.::..                      ||:.|::|:   |....
Mouse   130 DSSHKQRKKVIMQAFSREALQCYVPV----------------------IAEEVSSCLEQWLSCGE 172

  Fly   196 EAVLGVPIKKR--------------------GQDVAMMEDSPFRQGKIMMPARFTQPWLLLD--- 237
            ..:|..|..||                    |:|...:.:: |.:   |....|:.|   :|
Mouse   173 RGLLVYPEVKRLMFRIAMRILLGCEPGPAGGGEDEQQLVEA-FEE---MTRNLFSLP---IDVPF 230

  Fly   238 -GIYHWTKMANDELNQKKRLNDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEISESNRDFTEED 301
             |:|...|..|   ....|:.:..|..|:|.:..:.:.......:.|::|..|..|.    .:..
Mouse   231 SGLYRGVKARN---LIHARIEENIRAKIRRLQATEPDGGCKDALQLLIEHSWERGER----LDMQ 288

  Fly   302 IVNEACTFML-AGQDSVGAAVAFTLFLLTQNPECQDRCVLELAT--IFEDSNR--APTMTDLHEM 361
            .:.::.|.:| .|.::..:|....:..|...|....:...|:.:  :...||:  ...|..|.::
Mouse   289 ALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEIKSKGLLCKSNQDNKLDMETLEQL 353

  Fly   362 RYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPER 426
            :|....|||.|||.|.||...|...:...|..:.:|.|.||......||.:|.|:.:.|:|.|:|
Mouse   354 KYTGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVADIFTNKEEFNPDR 418

  Fly   427 FSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLR--SYQLL--PVTGKTT 481
            |...:.|:...::|:||..|.|.|:|..||.:.:|.....|.|  .:|||  |.|.||:
Mouse   419 FIVPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTS 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	104/468 (22%)
Cyp26a1	NP_031837.2	p450	43..491	CDD:299894	109/481 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910