Protein Alignment Cyp4aa1 and CYP4F22

DIOPT Version :9

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 146/535 - (27%)
• Similarity: 250/535 - (46%)
• Gaps: 68/535 - (12%)

  Fly    18 ILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNC--MLVTDKDLMRRC-------- 72
            :|.||.:..:.:..||.....|..:....||.    |.||..|  ..:|.:.|  ||
Human     8 LLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLL----LRFLRLCRSFYITCRRL--RCFPQPPRRN 66

  Fly    73 -------------AG-----KAFDLYGSLVRIWV-LLFPFFAVLEPEDLQVIL--SSKKHTNKVF 116
                         ||     |..|....::.:|: .:.|...::.|:.::.:|  |:........
Human    67 WLLGHLGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDL 131

  Fly   117 FYRLMHNFLGDGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTF---VDASQSLYENLDAEAVGT 178
            ||..:..:|||||:.|.|.|||.||||:.||||.::|:.::..|   .|...:.:.:| ||....
Human   132 FYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHL-AEGSAV 195

  Fly   179 EINIAKYVNNCVLDILNEAVLGV--PIKKRGQDV--AMMEDSPF---RQGKIMMPARFTQPWLLL 236
            .:::.::::...||.|.:.|...  ..:::..|.  |::|.|..   ||.::..         .|
Human   196 SLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHH---------YL 251

  Fly   237 DGIYHWTKMANDELNQKKRLNDFTRKMIQRRRQIQNNNNGNSERKC----LLDH----MIEISES 293
            |.||:.:............::.||.::||.||:........:..|.    .||.    ::...|.
Human   252 DFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDED 316

  Fly   294 NRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSN-RAPTMTD 357
            .::.::|||..||.|||..|.|:..:.:::.||.|.:.||.|::|..|:..:.:... ......|
Human   317 GKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDD 381

  Fly   358 LHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDPEK 421
            |.::.:..|||||:||.||.|.|::|:..|:::|.. ..:|.|....:..|.||....::||.:.
Human   382 LTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKV 446

  Fly   422 FQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATF 486
            :.|.||.|:|.:.|.|.|::|||||||.|||..||:.|::.:|:..|..:: |.|.....:....
Human   447 YNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFR-LSVDRTRKVRRKP 510

  Fly   487 RITLRASGGLWVRLK 501
            .:.||...|||::::
Human   511 ELILRTENGLWLKVE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	131/475 (28%)
CYP4F22	NP_775754.2	p450	60..524	CDD:278495	130/474 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154625
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750