Protein Alignment Cyp4aa1 and CYP4F8

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 158/516 - (30%)
• Similarity: 259/516 - (50%)
• Gaps: 51/516 - (9%)

  Fly    19 LILLVISLS---------IYTFYATLNTYLRSVLLSLRLTGPPSLP--FLGNCMLVTDKDLMRRC 72
            |:|||:..|         .|.||....        .||....|...  |||:..|||..:...|.
Human    20 LLLLVVGASWLLARILAWTYAFYHNGR--------RLRCFPQPRKQNWFLGHLGLVTPTEEGLRV 76

  Fly    73 AGKAFDLY-GSLVRIWVLLFPFFAVLEPEDLQ-VILSSKKHTNK-VFFYRLMHNFLGDGLITSSG 134
            ..:....| ...||....:.|...:..|:.:: ||.:|...|:| :.||:.:..:|||||:.|.|
Human    77 LTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVG 141

  Fly   135 SKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAV--GTEINIAKYVNNCVLDILNEA 197
            .||.:||||:.||||.|:|:.:|..|..::..::......|:  .|.:::.::::...||.|.:.
Human   142 DKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKC 206

  Fly   198 VLGVPI----KKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQKKRLND 258
            :.....    |......|:||.|      .::..|..|.:...|.:|..|..........:.::|
Human   207 IFSFDSNCQEKPSEYITAIMELS------ALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHD 265

  Fly   259 FTRKMIQRRRQ------IQNNNNGNSERKCL--LDHMIEISESN-RDFTEEDIVNEACTFMLAGQ 314
            ||..:||.||:      :.:.....::.|.|  :|.::...:.| ::.::|||..||.|||..|.
Human   266 FTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGH 330

  Fly   315 DSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP---TMTDLHEMRYMEMCIKEALRLYP 376
            |:..:.:::.|:.|.::||.|:||..|:..:.:|  |.|   ...||.::.::.||:||:|||:|
Human   331 DTTASGLSWVLYNLARHPEYQERCRQEVQELLKD--REPKEIEWDDLAQLPFLTMCLKESLRLHP 393

  Fly   377 SVPLIARKLGEEVRLA-KHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPYAF 440
            .:|..||...::|.|. ...:|.|:...|..:|.|....::||||.:.|.||.|||::.|.|.||
Human   394 PIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAF 458

  Fly   441 LPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLK 501
            :|||||||.|||.:||:.|:|.:::..|..:::||  .......|..|.|||..|||:|::
Human   459 IPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILP--DHREPRRTPEIVLRAEDGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	137/437 (31%)
CYP4F8	NP_009184.1	CYP4F	74..515	CDD:410772	140/450 (31%)