Protein Alignment Cyp4aa1 and cyp46a1.4

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: XP_002933245.2
• Gene: cyp46a1.4 / 100498621
• XenbaseID: XB-GENE-29072485
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 519
• Identity: 138/519 - (26%)
• Similarity: 238/519 - (45%)
• Gaps: 69/519 - (13%)

  Fly    21 LLVISLSIYTFYATLNTYLRSVLLSL-RLTGPPSLPFLGNCMLVTDK---------DLMRRCAGK 75
            ||:|..::..|.|.. .|::.:.|.. .:.|||...||...:....|         ||....|
 Frog    18 LLIIIGAVVAFLAYC-AYIKYMHLKYDDIPGPPRDSFLLGHIPTLSKAEENYSVVHDLFLHWA-- 79

  Fly    76 AFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHN-----FLGDGLITS-SG 134
              ::||.:.:|.:|.........||.::..|.|.|:....:.|..:.|     |||.||:|. ..
 Frog    80 --EIYGPVFKINILHRVMIYSTSPESVKECLMSSKYPKDPYTYNQLFNLFGKRFLGKGLLTDPDH 142

  Fly   135 SKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVG-TEINIAKYVNNCVLDILNEAV 198
            ..|.:.||::.|||.:..|::.|..|.:.::.:.|.|:.:|.| .|:::...:|...||::.:..
 Frog   143 DHWYHQRRIMDPAFSNTYLKEMIGIFNERAEQMMEKLEEKADGHQEVSMHSIINRVTLDVITKVA 207

  Fly   199 LGVPIKKRGQDVAMME----DSPFRQGKIM--MPARFTQPWLLLDGIY---HWTKMANDELNQKK 254
            .|:       |:.::|    |.|....|::  |......|::.    |   ||.     .:.:.:
 Frog   208 FGM-------DLGLVEGNKTDFPNAISKVLTGMMRYMQNPYMQ----YFPKHWA-----FVREVQ 256

  Fly   255 RLNDFTRK-----MIQRRRQIQNNNNGNSERKCLLDHMIEISESNRDFTEEDIVNEACTFMLAGQ 314
            ...|..||     :.||::.:|   ||....|.:|..:::.:|......:|.:::...||.:|||
 Frog   257 ESADLLRKTGKECISQRKKAMQ---NGEELPKDILTKILQCAELENALDDEIMLDNFITFFIAGQ 318

  Fly   315 DSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVP 379
            ::....::||:..||:.||...:..:|:..:. ...|..:..|:..:.||...:||:||.||..|
 Frog   319 ETTANQLSFTVMELTRQPEIMTKLRMEVDEVI-GFKRDISYDDIQNLNYMTQVLKESLRFYPPGP 382

  Fly   380 LIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPY-AFLPF 443
            ..:|.|.|:.......:|.|.::....|...|:...:.||.||.||||.|...:   || .:.||
 Frog   383 GTSRYLKEDTIFEGIKIPGGVSITFNTYVMGRMEKFFQDPCKFDPERFHPAAVK---PYFCYFPF 444

  Fly   444 SAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRI----TLRASGGLWVRLKER 503
            :.|||.|:|..|:.:|.|.|:|:|::.::...|.|:     :|.|    |||...|:...||.|
 Frog   445 ALGPRSCLGQIFSQLEAKVILSKLIQRFEFELVPGQ-----SFGIKDTGTLRPRDGVVCTLKSR 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	118/442 (27%)
cyp46a1.4	XP_002933245.2	CYP46A1-like	72..498	CDD:410706	122/457 (27%)