Protein Alignment Cyp4aa1 and Cyp3a59

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001098630.1
• Gene: Cyp3a59 / 100041449
• MGIID: 3769707
• Length: 503
• Species: Mus musculus
• Alignment Length: 500
• Identity: 127/500 - (25%)
• Similarity: 216/500 - (43%)
• Gaps: 64/500 - (12%)

  Fly     7 LERTTNLELCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNC------MLVTD 65
            :|...||.: ...:|||.||..:..|   .||...:...|.:.||..||..|..      |...|
Mouse     1 MELIPNLSI-ETWVLLVTSLVFFYIY---GTYSHGLFKKLGIPGPKPLPLFGTIFNYFDGMWKFD 61

  Fly    66 KDLMRRCAGKAFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLM---HNFLGD 127
            :|..::        ||.:...:|...|..|:::||.::::|  .|....||..|..   ..||..
Mouse    62 EDCYKK--------YGKIWGFYVGPKPILAIMDPEIIKIVL--VKECYSVFTNRPTLGPVGFLKK 116

  Fly   128 GLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENL-DAEAVGTEINIAKYVNNCVL 191
            .:..|...:|...|.|:.|.|....|::...........|..|| ..|..|..||:........:
Mouse   117 SITISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPINMKDIFGAYSM 181

  Fly   192 DILNEAVLGVPIKKRGQDVAMMEDSPF-RQGKIMMPARFTQPWLL-------LDGIYHWTKMA-- 246
            |::.....||.|     |......:|| ::.|.::..:...|:||       |..||....::
Mouse   182 DVITGTSFGVNI-----DSLNNPQNPFVQKTKKILKFKIFDPFLLSTILFPFLTPIYEMLNLSIF 241

  Fly   247 -NDELN---------QKKRLNDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEISESNRDFTEED 301
             .|.:|         :|:||....:..:...:.:.|..|...:            ||.:..::.:
Mouse   242 PRDSMNFFKKFVKRMKKERLASKQKNRVDFLQLMMNTQNSKGQ------------ESQKALSDLE 294

  Fly   302 IVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMTD-LHEMRYME 365
            :..:|..|:..|.|:...:::..::.|..:|:.|.:...|:....  .|:||...| |.:|.|::
Mouse   295 MAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTL--PNKAPVTYDALMDMEYLD 357

  Fly   366 MCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPE 430
            |.:.|:|||||:...:.|...::|.:....:|.|:.|.|..|..||....:|:|::|.|.|||.|
Mouse   358 MVVNESLRLYPTAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKE 422

  Fly   431 NSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLP 475
            |..|..||.::||..|||.|:..|||::.:|..|..:|:::.:.|
Mouse   423 NEGNIDPYIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQP 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	105/419 (25%)
Cyp3a59	NP_001098630.1	CYP3A	67..492	CDD:410743	106/429 (25%)