DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8299 and PRSS2

DIOPT Version :9

Sequence 1:	NP_611066.1	Gene:	CG8299 / 36751	FlyBaseID:	FBgn0034052	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	NP_001290343.1	Gene:	PRSS2 / 5645	HGNCID:	9483	Length:	261	Species:	Homo sapiens

Alignment Length:	270	Identity:	99/270 - (36%)
Similarity:	147/270 - (54%)	Gaps:	23/270 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLRLGLFLLAALGVVILTDSASISTHIVGGDQADIADFPYQVSVRLETYMLLHICGGSIYAPRV 65
            |:|.|.|..:||.......|    ...||||...:....|||||:. ..|   |.||||:.:.:.
Human     1 MNLLLILTFVAAAVAAPFDD----DDKIVGGYICEENSVPYQVSLN-SGY---HFCGGSLISEQW 57

  Fly    66 VITAAHCIK--------GRYASY--IRIVAGQNSIADLE--EQGVKVSKLIPHAGYNKKTYVNDI 118
            |::|.||.|        ||...|  |::..|:::|..||  ||.:..:|:|.|..||.:|..|||
Human    58 VVSAGHCYKSAINSKLSGRGCEYHRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDI 122

  Fly   119 GLIITREPLEYSALVQPIAVALEAPPSGAQAVVSGWGKRAEDDEALPAMLRAVELQIIEKSTCGA 183
            .||....|...::.|..|::....|.:|.::::||||.........|..|:.::..::.::.|.|
Human   123 LLIKLSSPAVINSRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEA 187

  Fly   184 QYLTKDYTVTDEMLCAGYLEGGKDTCNGDSGGPLAVDGVLVGVVSWGVGCGREGFPGVYTSVNSH 248
            .|..|   :|:.|.|.|:||||||:|.||||||:..:|.|.|:||||.||.::..|||||.|.::
Human   188 SYPGK---ITNNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNY 249

  Fly   249 IDWIEEQAEA 258
            :|||::...|
Human   250 VDWIKDTIAA 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8299	NP_611066.1	Tryp_SPc	27..252	CDD:214473	89/236 (38%)
CG8299	NP_611066.1	Tryp_SPc	28..255	CDD:238113	91/238 (38%)
PRSS2	NP_001290343.1	Tryp_SPc	23..253	CDD:214473	89/236 (38%)
PRSS2	NP_001290343.1	Tryp_SPc	24..256	CDD:238113	91/238 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	1	1.000	-	-		FOG0000102
OrthoInspector	1	1.000	-	-		otm41500
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920