DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8299 and PRSS1

DIOPT Version :9

Sequence 1:	NP_611066.1	Gene:	CG8299 / 36751	FlyBaseID:	FBgn0034052	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	253	Identity:	96/253 - (37%)
Similarity:	138/253 - (54%)	Gaps:	18/253 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLAALGVVILTDSASISTHIVGGDQADIADFPYQVSVRLETYMLLHICGGSIYAPRVVITAAHC 72
            |:.|||......|.     .||||...:....|||||:. ..|   |.||||:...:.|::|.||
Human   234 FVAAALAAPFDDDD-----KIVGGYNCEENSVPYQVSLN-SGY---HFCGGSLINEQWVVSAGHC 289

  Fly    73 IKGRYASYIRIVAGQNSIADLE--EQGVKVSKLIPHAGYNKKTYVNDIGLIITREPLEYSALVQP 135
            .|.|    |::..|:::|..||  ||.:..:|:|.|..|::||..|||.||........:|.|..
Human   290 YKSR----IQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVST 350

  Fly   136 IAVALEAPPSGAQAVVSGWGKRAEDDEALPAMLRAVELQIIEKSTCGAQYLTKDYTVTDEMLCAG 200
            |::....|.:|.:.::||||..|......|..|:.::..::.::.|.|.|..|   :|..|.|.|
Human   351 ISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGK---ITSNMFCVG 412

  Fly   201 YLEGGKDTCNGDSGGPLAVDGVLVGVVSWGVGCGREGFPGVYTSVNSHIDWIEEQAEA 258
            :||||||:|.||||||:..:|.|.||||||.||.::..|||||.|.:::.||:....|
Human   413 FLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAA 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8299	NP_611066.1	Tryp_SPc	27..252	CDD:214473	88/226 (39%)
CG8299	NP_611066.1	Tryp_SPc	28..255	CDD:238113	90/228 (39%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	88/226 (39%)
		Tryp_SPc	249..467	CDD:238113	90/228 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBP0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	1	1.000	-	-		FOG0000102
OrthoInspector	1	1.000	-	-		otm41500
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820