DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Diap2 and BIRC7

DIOPT Version :9

Sequence 1:	NP_477127.1	Gene:	Diap2 / 36748	FlyBaseID:	FBgn0015247	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_647478.1	Gene:	BIRC7 / 79444	HGNCID:	13702	Length:	298	Species:	Homo sapiens

Alignment Length:	379	Identity:	111/379 - (29%)
Similarity:	155/379 - (40%)	Gaps:	110/379 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 DHVKCVWCNGVIAKWEKNDNAFEEHKRFFPQC-PRVQMGPLIEFATGKNLDE-----LG-IQPTT 202
            |..||:......:.|...|...:|      :| ||....|::...|.:..|.     || ::|.|
Human     5 DSAKCLHRGPQPSHWAAGDGPTQE------RCGPRSLGSPVLGLDTCRAWDHVDGQILGQLRPLT 63

  Fly   203 L--------------PLRPKYACVDARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFHCN 253
            .              |..|.....:.||.:|.|||::...|...||.||.::....|:||||.|.
Human    64 EEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCY 128

  Fly   254 IGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVSEVLATTAANASS-QPATAPAPTLQADVLM 317
            .||:||::.|:||.|||||.|.|||:|.:||..:|..|..|.:....| .|...|.
Human   129 GGLQSWKRGDDPWTEHAKWFPSCQFLLRSKGRDFVHSVQETHSQLLGSWDPWEEPE--------- 184

  Fly   318 DEAPAKEALALGIDGGVVRNAIQRKLLSSGCAFSTLDELLHDIFDDAGAGAALEVREPPEPSAPF 382
            |.||.                                                   .|..|::.:
Human   185 DAAPV---------------------------------------------------APSVPASGY 198

  Fly   383 IE---PCQATTSKAASVPIPVADSIPAKPQAAEAVANISKITDEIQKMSVATPNGNLSLEEENRQ 444
            .|   |.:...|::|..|..|:   ||:.|.|               ..|..|.|...:|.:.|:
Human   199 PELPTPRREVQSESAQEPGGVS---PAEAQRA---------------WWVLEPPGARDVEAQLRR 245

  Fly   445 LKDARLCKVCLDEEVGVVFLPCGHLATCNQCAPSVANCPMCRADIKGFVRTFLS 498
            |::.|.||||||..|.:||:||||| .|.:|||.:..||:|||.::..||||||
Human   246 LQEERTCKVCLDRAVSIVFVPCGHL-VCAECAPGLQLCPICRAPVRSRVRTFLS 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Diap2	NP_477127.1	BIR	12..78	CDD:237989
		BIR	112..181	CDD:197595	9/36 (25%)
		BIR	213..281	CDD:237989	33/67 (49%)
		UBA_IAPs	320..363	CDD:270506	2/42 (5%)
		zf-C3HC4_3	447..492	CDD:290631	24/44 (55%)
BIRC7	NP_647478.1	BIR	88..155	CDD:237989	33/66 (50%)
BIRC7	NP_647478.1	zf-C3HC4_3	248..292	CDD:290631	24/44 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140725
Domainoid	1	1.000	80	1.000	Domainoid score	I8611
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340284at2759
OrthoFinder	1	1.000	-	-		FOG0000512
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100552
Panther	1	1.100	-	-	O	PTHR10044
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R141
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.740