Protein Alignment Diap2 and Birc3

DIOPT Version :10

• Sequence 1: NP_477127.1
• Gene: Diap2 / 36748
• FlyBaseID: FBgn0015247
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_076477.3
• Gene: Birc3 / 78971
• RGDID: 621282
• Length: 638
• Species: Rattus norvegicus
• Alignment Length: 593
• Identity: 178/593 - (30%)
• Similarity: 274/593 - (46%)
• Gaps: 122/593 - (20%)

  Fly     9 ESVRLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSPIC 73
            |..||:|:..:|...|||...|...||:.||...:.:|..|.:.:|.|:.||...|:||:..|.|
  Rat    65 ELYRLSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFSCGLMLDNWKQGDSPIEKHRKLYPSC 129

  Fly    74 SMVLAPNHCGNVPRSQE-----------------SDNEG----------NSVVDSPESCSCP--- 108
            |.|...|...::..|.:                 |::.|          :..|:...:..||
  Rat   130 SFVQTLNPANSLEASPQPPLPSTATSTMPSGFAASESTGYFSGSYSSFPSDPVNFRANQDCPAFS 194

  Fly   109 ------DLLLEANRLVTFKDWPNPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFE 167
                  .:..|..||:|::.||...::|..||||||||....|.|.|..|.|.::.|::.|:...
  Rat   195 TSPYHFAMNTEKARLLTYQTWPLSFLSPAELAKAGFYYTGPGDRVACFACGGKLSNWDRKDDPLS 259

  Fly   168 EHKRFFPQCPRVQ-MGPLIEFATGKNLDELGIQPTTLPLRPKYACVDARLRTFTDWPISNIQPAS 231
            ||:|.||.||.:: :|   :|.:...:..|.:|...           ||:|||:.||.|.:....
  Rat   260 EHRRHFPSCPFLKDVG---QFTSQYTVSNLSMQTHA-----------ARVRTFSTWPSSALVHPQ 310

  Fly   232 ALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVSEV----- 291
            .||.||.||....|.|:||.|:.|||.|:..|:||.|||||.|:|::::..||..:|.:|
  Rat   311 ELASAGFYYTGHSDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEYLIRIKGQEFVGQVQAGYP 375

  Fly   292 -----LATTAANASSQPATA------PAPTLQADVLMDEAPAKEALALGIDGGVVRNAIQRKLLS 345
                 |.:|:.:...:...|      |....:..|:|:....|.||.:|....:||..:||::|:
  Rat   376 HLLEQLLSTSDSPEDETGEAAIVHLGPGENWEDAVMMNTPVVKAALDMGFSRSLVRQTVQRQILA 440

  Fly   346 SGCAFSTLDELLHDIFDDAGAGAALEVR-EPPEPSAPFIEPCQATTSKAASVPI-----PVA--- 401
            :|..:.|:.:|:..:.|     |..|:| |..|..|...|....|..:...:.:     ||.
  Rat   441 TGENYRTVSDLVIGLLD-----AEDEMREEQTEQEAEEEESDDLTLIRKNKMVLLQHLTPVTPIL 500

  Fly   402 --------------DSIPAKPQAAEAVANISKI-----------TDEIQKM-------------- 427
                          |::..||...:|...|..:           .:.:|::
  Rat   501 DCLLSARVITEQEYDAVKQKPHTLQARTLIDTVLAKGNTAATSFRNSLQEIDPGLYRDIFVRQNI 565

  Fly   428 -SVATPN-GNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHLATCNQCAPSVANCPMCRADIK 490
             |:.|.: ..|.:||:.|:|::.|.||||:|.||.:||:|||||..|.:||||:..||:||..||
  Rat   566 RSLPTDDIAALPMEEQLRKLQEERTCKVCMDREVSLVFIPCGHLVVCKECAPSLRKCPICRGTIK 630

  Fly   491 GFVRTFLS 498
            |.||||||
  Rat   631 GTVRTFLS 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Diap2	NP_477127.1	BIR	12..78	CDD:237989	25/65 (38%)
		BIR	112..181	CDD:197595	29/69 (42%)
		BIR	213..281	CDD:237989	33/67 (49%)
		UBA_IAPs	320..363	CDD:270506	12/42 (29%)
		RING-HC_BIRC2_3_7	442..498	CDD:438373	33/55 (60%)
Birc3	NP_076477.3	BIR	64..133	CDD:197595	25/67 (37%)
		BIR	206..272	CDD:237989	28/65 (43%)
		BIR	290..358	CDD:197595	33/78 (42%)
		UBA_BIRC2_3	412..461	CDD:270577	15/53 (28%)
		DD	476..564	CDD:472698	9/87 (10%)
		RING-HC_BIRC2_3_7	582..638	CDD:438373	33/55 (60%)