DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Diap2 and Birc2

DIOPT Version :9

Sequence 1:	NP_477127.1	Gene:	Diap2 / 36748	FlyBaseID:	FBgn0015247	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_068520.2	Gene:	Birc2 / 60371	RGDID:	620690	Length:	589	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	176/584 - (30%)
Similarity:	264/584 - (45%)	Gaps:	113/584 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ESVRLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSPIC 73
            |..|::|:..:|...|||...|...||:.||...:.:|..|.:.:|.|:.||...|:||:..|.|
  Rat    25 ELYRMSTYSAFPRGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPTEKHRQFYPSC 89

  Fly    74 SMVLA------------------------PNHCGNVPRSQESDNEGNSVVDS----PESCSCPDL 110
            |.|..                        |...|.:..|..|:...:..|:.    ...||.. :
  Rat    90 SFVQTLLSGGLQSAAKNTSPAKSRFAHSLPLEQGGIHSSLPSNPLNSRAVEDFSLRMNPCSYA-M 153

  Fly   111 LLEANRLVTFKDWPNPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKRFFPQ 175
            ..|..|.:::..||...::|..||||||||....|.|.|..|.|.::.||.||:...||:|.||.
  Rat   154 STEEARFLSYSMWPLSFLSPAELAKAGFYYTGPGDRVACFACGGKLSNWEPNDDPLSEHRRHFPH 218

  Fly   176 CPRVQMGPLIEFATGK----NLDELGIQPTTLPLRPKYACVDARLRTFTDWPISNIQPASALAQA 236
            ||.::       .|.:    ::..|.:|..:           ||:|||..||.|.:.....||.|
  Rat   219 CPFLE-------NTSETQRFSVSNLSMQTHS-----------ARMRTFLYWPSSVLVQPEQLASA 265

  Fly   237 GLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVSEV---------- 291
            |.||....|.|:||.|:.|||.|:..|:||.|||||.|:|:|::..||..:|.|:
  Rat   266 GFYYVDHNDDVKCFCCDGGLRCWEPGDDPWIEHAKWFPRCEFLIRMKGQEFVDEIQARYPHLLEQ 330

  Fly   292 LATTAANASSQPATAPAPTL------QADVLMDEAPAKEALALGIDGGVVRNAIQRKLLSSGCAF 350
            |.:|:..:..:.|..|...|      :..|:|:....|.||.:|....:||..:||::|::|..:
  Rat   331 LLSTSDTSEEENADPPVVHLGPGENWEDAVMMNTPVVKAALDMGFSRSLVRQTVQRQILATGENY 395

  Fly   351 STLDELLHDIFDDAGAGAALEVREPPEPSA----------------------PFIEPCQATT--- 390
            .|:.:::..:.:........|.....|.:|                      |.::.....:
  Rat   396 RTVSDIVSALLNAEDERREEEKERQSEETASGDLSLIRKNRMALFQQLTCVIPILDDLLEASVLT 460

  Fly   391 -------SKAASVPI---PVADSIPAKPQAAEAV-ANISKITDE-------IQKMSVATPN---G 434
                   .:...:|:   .:.|:|..|..||.:| .|..|..|.       ::|.....|.   .
  Rat   461 KEEHDIIRQKTQIPLQARELIDTILVKGNAAASVFKNSLKEVDSTLYEHLFVEKTMKYIPTEDVS 525

  Fly   435 NLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHLATCNQCAPSVANCPMCRADIKGFVRTFLS 498
            .|||||:.|:|::.|.||||:|.||.:||:|||||..|.:||||:..||:||..|||.||||||
  Rat   526 GLSLEEQLRRLQEERTCKVCMDREVSIVFIPCGHLVVCRECAPSLRKCPICRGTIKGTVRTFLS 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Diap2	NP_477127.1	BIR	12..78	CDD:237989	24/65 (37%)
		BIR	112..181	CDD:197595	29/68 (43%)
		BIR	213..281	CDD:237989	34/67 (51%)
		UBA_IAPs	320..363	CDD:270506	11/42 (26%)
		zf-C3HC4_3	447..492	CDD:290631	26/44 (59%)
Birc2	NP_068520.2	BIR	24..93	CDD:197595	24/67 (36%)
		BIR	155..224	CDD:197595	29/75 (39%)
		BIR	240..308	CDD:197595	33/78 (42%)
		UBA_BIRC2_3	362..408	CDD:270577	12/45 (27%)
		CARD_BIRC2_BIRC3	425..514	CDD:260038	12/88 (14%)
		zf-C3HC4_3	538..583	CDD:290631	26/44 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334415
Domainoid	1	1.000	82	1.000	Domainoid score	I8204
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H900
Inparanoid	1	1.050	265	1.000	Inparanoid score	I2975
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340284at2759
OrthoFinder	1	1.000	-	-		FOG0000512
OrthoInspector	1	1.000	-	-		otm44468
orthoMCL	1	0.900	-	-		OOG6_100552
Panther	1	1.100	-	-	O	PTHR10044
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X559
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.760