DRSC/TRiP Functional Genomics Resources

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Protein Alignment Diap2 and NLRC4

DIOPT Version :10

Sequence 1:NP_477127.1 Gene:Diap2 / 36748 FlyBaseID:FBgn0015247 Length:498 Species:Drosophila melanogaster
Sequence 2:NP_067032.3 Gene:NLRC4 / 58484 HGNCID:16412 Length:1024 Species:Homo sapiens


Alignment Length:444 Identity:80/444 - (18%)
Similarity:135/444 - (30%) Gaps:160/444 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 CSMVLAPNHCGNVPRSQESDN--EGNSVVDSPESCSCPDLLLEANRLVTFKDWPNPNITPQALAK 135
            |.:.|..........|||.:.  :|.|:..:  |.:.||.|.:     .|:..||       .|.
Human   557 CGIHLYQESTSKSALSQEFEAFFQGKSLYIN--SGNIPDYLFD-----FFEHLPN-------CAS 607

  Fly   136 AGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKRFFPQCPRVQMGPLIEFATGKNLDELGIQP 200
            |       ||.:|..:..|.:|.|||                      ..|...|.:::|  ...
Human   608 A-------LDFIKLDFYGGAMASWEK----------------------AAEDTGGIHMEE--APE 641

  Fly   201 TTLPLR---------PKYACVDARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFHCNIGL 256
            |.:|.|         .::..::..||.|:.....:|:          |..||      |.....|
Human   642 TYIPSRAVSLFFNWKQEFRTLEVTLRDFSKLNKQDIR----------YLGKI------FSSATSL 690

  Fly   257 RSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVSEVLATTAANASSQPATAPAPTLQAD------- 314
            |...|             :|      .|.|....::.:|..|..|....|...|::.:       
Human   691 RLQIK-------------RC------AGVAGSLSLVLSTCKNIYSLMVEASPLTIEDERHITSVT 736

  Fly   315 -------------------------------VLMDEAPAKEALALGIDGGVVRNAIQRKLLSSGC 348
                                           ::||.....|..|:.:..|:       |.|...|
Human   737 NLKTLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDAIKLAEGL-------KNLKKMC 794

  Fly   349 AFSTLDELLHDIFDDAGAGAALEVREPPEPSAPFIEPCQATTSKAASVPIPVADSIPAKPQAAEA 413
            .|    .|.|  ..|.|.|....|:....      |||.....:..|..:           :|.|
Human   795 LF----HLTH--LSDIGEGMDYIVKSLSS------EPCDLEEIQLVSCCL-----------SANA 836

  Fly   414 VANISKITDEIQKMSVATPNGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCG 467
            |..:::....:.|:|:...:.|. ||::..:.....:.::.:.|::..:.||.|
Human   837 VKILAQNLHNLVKLSILDLSENY-LEKDGNEALHELIDRMNVLEQLTALMLPWG 889

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Diap2NP_477127.1 BIR 12..78 CDD:237989 1/4 (25%)
BIR 112..181 CDD:197595 13/68 (19%)
BIR 213..281 CDD:237989 12/67 (18%)
UBA_IAPs 320..363 CDD:270506 9/42 (21%)
RING-HC_BIRC2_3_7 442..498 CDD:438373 4/26 (15%)
NLRC4NP_067032.3 CARD 1..87 CDD:459874
Nucleotide-binding domain (NBD). /evidence=ECO:0000250 95..298
NACHT 148..>469 CDD:444362
NACHT 163..316 CDD:428606
Winged-helix domain (WHD). /evidence=ECO:0000250 356..463
NLRC4_HD 465..579 CDD:436120 5/21 (24%)
LRR 1 578..598 6/26 (23%)
LRR 646..>955 CDD:443914 51/310 (16%)
LRR 2 656..679 4/32 (13%)
leucine-rich repeat 691..713 CDD:275381 6/40 (15%)
LRR 3 735..758 0/22 (0%)
leucine-rich repeat 738..764 CDD:275380 0/25 (0%)
LRR 4 762..785 4/22 (18%)
leucine-rich repeat 765..789 CDD:275380 5/30 (17%)
LRR 5 787..812 9/37 (24%)
leucine-rich repeat 790..817 CDD:275380 9/32 (28%)
leucine-rich repeat 822..849 CDD:275380 4/37 (11%)
LRR 6 824..847 4/33 (12%)
LRR 7 848..870 5/22 (23%)
leucine-rich repeat 850..880 CDD:275380 4/30 (13%)
LRR 8 878..902 4/12 (33%)
leucine-rich repeat 881..908 CDD:275380 3/9 (33%)
leucine-rich repeat 909..938 CDD:275380
LRR 9 911..933
LRR 10 936..963
leucine-rich repeat 939..966 CDD:275380
LRR 11 965..985
LRR 12 999..1021
Blue background indicates that the domain is not in the aligned region.

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