DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Diap2 and NAIP

DIOPT Version :9

Sequence 1:	NP_477127.1	Gene:	Diap2 / 36748	FlyBaseID:	FBgn0015247	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001333799.1	Gene:	NAIP / 4671	HGNCID:	7634	Length:	1403	Species:	Homo sapiens

Alignment Length:	353	Identity:	98/353 - (27%)
Similarity:	152/353 - (43%)	Gaps:	76/353 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MELESVRLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVA----ERH 66
            |..|:.||.||..:...:....:::.|.||:.||.....:|..|.:.:    :|..:.    |.|
Human    57 MRSEAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLIL----FGAGLTRLPIEDH 117

  Fly    67 RRSSPICSMVLAPNHCGNVP------RSQESDNEGNSVVDSPESCSCPDLLLEANRLVTFKDWP- 124
            :|..|.|..:|..: .||:.      ::.:|...|..:....|..          ||.:|::||
Human   118 KRFHPDCGFLLNKD-VGNIAKYDIRVKNLKSRLRGGKMRYQEEEA----------RLASFRNWPF 171

  Fly   125 -NPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKRFFPQCPRVQMGPLIEFA 188
             ...|:|..|::|||.:..:.|.|:|..|.|.:..||:.|:.::||.::||:|         ||.
Human   172 YVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKC---------EFL 227

  Fly   189 TGKNLDE---------LGIQPTT------------LPLRPKYACVDA-------RLRTFTDWPIS 225
            ..|...|         .|....|            ||:...| |.|:       ||.:|.|||..
Human   228 RSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAY-CNDSIFAYEELRLDSFKDWPRE 291

  Fly   226 NIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVS- 289
            :....:|||:|||:|..|.|.|:||.|...|..||:.|:|..:|.:..|.|.|:...|..|.|:
Human   292 SAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQNMKSSAEVTP 356

  Fly   290 ---------EVLATTA-ANASSQPATAP 307
                     |:|.||: :|.....|..|
Human   357 DLQSRGELCELLETTSESNLEDSIAVGP 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Diap2	NP_477127.1	BIR	12..78	CDD:237989	17/69 (25%)
		BIR	112..181	CDD:197595	24/70 (34%)
		BIR	213..281	CDD:237989	29/74 (39%)
		UBA_IAPs	320..363	CDD:270506
		zf-C3HC4_3	447..492	CDD:290631
NAIP	NP_001333799.1	BIR 1	60..127		18/70 (26%)
		BIR 2	159..227		26/86 (30%)
		BIR 3	278..345		27/66 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140726
Domainoid	1	1.000	80	1.000	Domainoid score	I8611
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.700