DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Diap2 and xiap

DIOPT Version :9

Sequence 1:	NP_477127.1	Gene:	Diap2 / 36748	FlyBaseID:	FBgn0015247	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_919377.2	Gene:	xiap / 373108	ZFINID:	ZDB-GENE-030825-7	Length:	405	Species:	Danio rerio

Alignment Length:	524	Identity:	138/524 - (26%)
Similarity:	204/524 - (38%)	Gaps:	163/524 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ELESVRLA-----------TFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGD 60
            ||||..:|           :|..:|.:..:||:.|...||:.||.....:|..|...:..|..||
Zfish     9 ELESDNVAADWSVMKNRVNSFQRFPYSEDISAQRLARAGFYFTGEGDRVQCFSCSATVQNWNRGD 73

  Fly    61 QVAERHRRSSPICSMVLAPNHCGNVPRSQES------DNEGNS---------VVDSPESCSCPDL 110
            ...|||:.:||.|..:    .|.:..|:..|      |.|..:         |||.......|.:
Zfish    74 TPLERHQLASPDCRFL----SCAHGMRNSNSIQSPDYDEEAENREFLLRTGEVVDESMYPVVPHM 134

  Fly   111 LLEANRLVTFKDWP-NPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKRFFP 174
            ..|..||.||.:|| :..:.|:.||:||.||:...|:|:|..|.|.::.||:.|:.:.||.:::.
Zfish   135 KSEEARLSTFNNWPADSPVRPEDLAEAGMYYIGIDDNVQCFCCGGGLSGWEQGDDPWSEHAKYYS 199

  Fly   175 QCPRVQMGPLIEFATGKNLDELGIQPTTLPLRPKY-----ACVDARLRTF--TDWPISNIQPASA 232
            .|         .|..|.|   :|..|.|.| ||:.     ...:.||.:|  ...||.    ...
Zfish   200 NC---------FFFLGHN---VGNVPLTTP-RPRVNVHPTDTFEGRLDSFKGRQHPID----PER 247

  Fly   233 LAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVSEVLATTAA 297
            ||:||.|.....|:|.||.|..|:::|..:::||.|||:..|.|.|:|..||..|||.|
Zfish   248 LARAGFYSTGEQDRVMCFRCGGGVKAWMPDEDPWEEHARHYPGCSFLLAEKGEEYVSSV------ 306

  Fly   298 NASSQPATAPAPTLQADVLMDEAPAKEALALGIDGGVVRNAIQRKLLSSGCAFSTLDELLHDIFD 362
                |......||...                              .||..:.|:...|:|
Zfish   307 ----QLRYPKRPTQNG------------------------------FSSHESGSSAQALIH---- 333

  Fly   363 DAGAGAALEVREPPEPSAPFIEPCQATTSKAASVPIPVADSIPAKPQAAEAVANISKITDEIQKM 427
              |:....|..|.|                                            ..|::|
Zfish   334 --GSSDMFEKAEDP--------------------------------------------MTELEK- 351

  Fly   428 SVATPNGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHLATCNQCAPSVANCPMCRADIKGF 492
                             |:..:|||||:|.::.:||:|||||.||.:|:.|:..||:|.|.|...
Zfish   352 -----------------LQREKLCKVCMDSDISIVFIPCGHLVTCQKCSASLDKCPICCATITQK 399

  Fly   493 VRTF 496
            ::|:
Zfish   400 IKTY 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Diap2	NP_477127.1	BIR	12..78	CDD:237989	21/76 (28%)
		BIR	112..181	CDD:197595	25/69 (36%)
		BIR	213..281	CDD:237989	25/69 (36%)
		UBA_IAPs	320..363	CDD:270506	5/42 (12%)
		zf-C3HC4_3	447..492	CDD:290631	22/44 (50%)
xiap	NP_919377.2	BIR	23..89	CDD:237989	20/65 (31%)
		BIR	138..206	CDD:237989	25/76 (33%)
		BIR	230..296	CDD:237989	25/69 (36%)
		zf-C3HC4_3	354..398	CDD:290631	22/43 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573440
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46946
OrthoDB	1	1.010	-	-		D1340284at2759
OrthoFinder	1	1.000	-	-		FOG0000512
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100552
Panther	1	1.100	-	-	O	PTHR10044
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R141
SonicParanoid	1	1.000	-	-		X559
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.850