Protein Alignment Diap2 and XIAP

DIOPT Version :9

• Sequence 1: NP_477127.1
• Gene: Diap2 / 36748
• FlyBaseID: FBgn0015247
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_001158.2
• Gene: XIAP / 331
• HGNCID: 592
• Length: 497
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 161/548 - (29%)
• Similarity: 241/548 - (43%)
• Gaps: 118/548 - (21%)

  Fly     3 ELGMELESV----RLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVA 63
            ::..|.|.|    ||.||..:|..:||||..|...||..||......|..||..:|||:|||...
Human    16 DINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAV 80

  Fly    64 ERHRRSSPICSMV----------------------LAPNHCGN-----VPRSQESDNE----GNS 97
            .|||:.||.|..:                      ...|:.|:     :.|..|:..:    ...
Human    81 GRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQ 145

  Fly    98 VVDSPESC--SCPDLLLEANRLVTFKDWPN-PNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKW 159
            |||..::.  ..|.:..|..||.:|::||: .::||:.||.||.||....|.|:|..|.|.:..|
Human   146 VVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNW 210

  Fly   160 EKNDNAFEEHKRFFPQCPRVQMGPLIEFATGKNL-----------DELGIQPTTLPLRPKYACVD 213
            |..|.|:.||:|.||.|         .|..|:||           |......|.||..|..|..:
Human   211 EPCDRAWSEHRRHFPNC---------FFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYE 266

  Fly   214 ARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQF 278
            ||:.||..| |.::. ...||:||.|....||:|:||||..||..|:..::||.:||||.|.|::
Human   267 ARIFTFGTW-IYSVN-KEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKY 329

  Fly   279 VLLAKGPAYVSEVLATTAANASSQPATAPAPTLQA---DVLMDEAPAKEALALGIDGGVVRNAIQ 340
            :|..||..|::.:..|.:........|...|:|..   |.:......:||:.:|.....::..::
Human   330 LLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIME 394

  Fly   341 RKLLSSGCAFSTLDELLHDIFDDAGAGAALEVREPPEPSAPFIEPCQATTSKAASVPIPVADSIP 405
            .|:..||..:.:|:.|                                           |||.:.
Human   395 EKIQISGSNYKSLEVL-------------------------------------------VADLVN 416

  Fly   406 AKPQAAEAVANISKITDEIQKMSVATPNGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHLA 470
            |:..:.:..::.:.:..||            |.||:.|:|::.:|||:|:|..:.:||:|||||.
Human   417 AQKDSMQDESSQTSLQKEI------------STEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLV 469

  Fly   471 TCNQCAPSVANCPMCRADIKGFVRTFLS 498
            ||.|||.:|..||||...|....:.|:|
Human   470 TCKQCAEAVDKCPMCYTVITFKQKIFMS 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Diap2	NP_477127.1	BIR	12..78	CDD:237989	29/87 (33%)
		BIR	112..181	CDD:197595	29/69 (42%)
		BIR	213..281	CDD:237989	29/67 (43%)
		UBA_IAPs	320..363	CDD:270506	8/42 (19%)
		zf-C3HC4_3	447..492	CDD:290631	23/44 (52%)
XIAP	NP_001158.2	BIR 1	26..93		29/66 (44%)
		BIR	28..95	CDD:237989	29/66 (44%)
		Interaction with caspase-7	141..149		2/7 (29%)
		BIR	162..232	CDD:197595	30/78 (38%)
		BIR 2	163..230		29/75 (39%)
		BIR	265..331	CDD:197595	29/67 (43%)
		BIR 3	265..330		29/66 (44%)
		UBA_BIRC4_8	370..419	CDD:270578	12/91 (13%)
		RING-HC_BIRC4_8	436..497	CDD:319628	29/60 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140728
Domainoid	1	1.000	76	1.000	Domainoid score	I8961
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46946
OrthoDB	1	1.010	-	-		D1340284at2759
OrthoFinder	1	1.000	-	-		FOG0000512
OrthoInspector	1	1.000	-	-		otm40338
orthoMCL	1	0.900	-	-		OOG6_100552
Panther	1	1.100	-	-	O	PTHR10044
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R141
SonicParanoid	1	1.000	-	-		X559
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.750