DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Diap2 and Birc7

DIOPT Version :9

Sequence 1:	NP_477127.1	Gene:	Diap2 / 36748	FlyBaseID:	FBgn0015247	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001156719.1	Gene:	Birc7 / 329581	MGIID:	2676458	Length:	285	Species:	Mus musculus

Alignment Length:	354	Identity:	101/354 - (28%)
Similarity:	140/354 - (39%)	Gaps:	117/354 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 KNDNAFEEHKRFFPQCP--------------RVQMGPLIEFATGKNLDELGIQPTTLPLRPKYAC 211
            :.|.:....::..|.||              ..|:.||.|.........||     .|..|:...
Mouse    33 REDGSGRTQEQDKPHCPCNHVLGQDCLDGQILGQLRPLSEEEESSGAAFLG-----EPAFPEMDS 92

  Fly   212 VDARLRTFTDWP-ISNIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPK 275
            .|.||.:|.||| .:.||| ..||.||.::....|:||||.|..||:||::.|:||.|||:|.|:
Mouse    93 EDLRLASFYDWPSTAGIQP-EPLAAAGFFHTGQQDKVRCFFCYGGLQSWERGDDPWTEHARWFPR 156

  Fly   276 CQFVLLAKGPAYVSEVLATTAANASSQPATAPAPTLQADVLMDEAPAKEALALGIDGGVVRNAIQ 340
            |||:|.:||..:|..:...|             |.|
Mouse   157 CQFLLRSKGRDFVERIQTYT-------------PLL----------------------------- 179

  Fly   341 RKLLSSGCAFSTLDELLHDIFDDAGAGAALEVREPPEPSAPFIEPCQATTSKAASVPIPVADSIP 405
                                       .:.:.||.||                        |::.
Mouse   180 ---------------------------GSWDQREEPE------------------------DAVS 193

  Fly   406 AKPQA-AEAVANISKITDEIQKMSVATPNGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHL 469
            |.|.| |.....:.:...|.|...|:.| |...::|:.|||::.|.||||||..|.:||:||||.
Mouse   194 ATPSAPAHGSPELLRSRRETQPEDVSEP-GAKDVQEQLRQLQEERRCKVCLDRAVSIVFVPCGHF 257

  Fly   470 ATCNQCAPSVANCPMCRADIKGFVRTFLS 498
             .|.:|||::..||:||..|...||||||
Mouse   258 -VCTECAPNLQLCPICRVPICSCVRTFLS 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Diap2	NP_477127.1	BIR	12..78	CDD:237989
		BIR	112..181	CDD:197595	4/33 (12%)
		BIR	213..281	CDD:237989	35/68 (51%)
		UBA_IAPs	320..363	CDD:270506	0/42 (0%)
		zf-C3HC4_3	447..492	CDD:290631	23/44 (52%)
Birc7	NP_001156719.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..47		1/13 (8%)
		BIR	94..161	CDD:237989	35/67 (52%)
		BIR	96..161		34/65 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..225		14/65 (22%)
		zf-C3HC4_3	235..279	CDD:290631	23/44 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830695
Domainoid	1	1.000	82	1.000	Domainoid score	I8391
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000512
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100552
Panther	1	1.100	-	-	O	PTHR10044
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R141
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.730