DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Diap2 and Birc6

DIOPT Version :9

Sequence 1:	NP_477127.1	Gene:	Diap2 / 36748	FlyBaseID:	FBgn0015247	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001164067.1	Gene:	Birc6 / 313876	RGDID:	1307247	Length:	4865	Species:	Rattus norvegicus

Alignment Length:	344	Identity:	85/344 - (24%)
Similarity:	131/344 - (38%)	Gaps:	58/344 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 ELGIQPTTLPLRPKYACVDARLRTFTDWPISN---IQPASALAQAGLYYQKIG---DQVRCFHCN 253
            |||:.|.....|........|..|||.||...   .|| ..:||||.|:|...   |:..||.|:
  Rat   272 ELGVGPGRSVDRALMYSEANRRETFTSWPHVGYRWAQP-DPMAQAGFYHQPASSGDDRAMCFTCS 335

  Fly   254 IGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVSEVLATTAANASSQ---------------- 302
            :.|..|:..||||.||.:.||.|.||   ||....:..|:.|.|.:.:|
  Rat   336 VCLVCWEPTDEPWSEHERHSPNCPFV---KGEHTQNVPLSVTLATSPAQLPSADGADRISCFGSG 397

  Fly   303 --PATAPAPTLQADVLMDEAPAKEALALGIDGGVVRNAIQRKLLSSGCAFSTLDE------LLHD 359
              |....|.|.:..:.:.:......:.|..:.......|.::|:.||...|.:|.      .|.|
  Rat   398 SCPQFLAAATKRGKICIWDVSKLMKVHLKFEINAYDPVIVQQLILSGDPSSGVDSRRPTLAWLED 462

  Fly   360 IFD-------DAGAGAALEVREPPEPSAPFIEPCQATTSKAASVPIPV-ADSIPAKPQAA--EAV 414
            ...       :..:...||..:..|.|.........:..:|..|.:.: |.||..:|:..  |.|
  Rat   463 SSSCSDIPKLEGDSDDLLEDSDSEEHSRSDSVTGHTSQKEAMEVSLDITALSILQQPEKLQWEIV 527

  Fly   415 ANISKITDEIQKMSVATPNGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPC---GHLATCNQCA 476
            ||:  :.|.::.:.....|..|: ..::.:.|:..      .|:..:.| ||   |.|.|....|
  Rat   528 ANV--LEDTVKDLEELGANPCLT-NSKSEKTKEKH------QEQHNIPF-PCLLAGGLLTYKSPA 582

  Fly   477 PSVANCPMCRADIKGFVRT 495
            .|..:....|: :.|..||
  Rat   583 TSPISSNSHRS-LDGLSRT 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Diap2	NP_477127.1	BIR	12..78	CDD:237989
		BIR	112..181	CDD:197595
		BIR	213..281	CDD:237989	31/73 (42%)
		UBA_IAPs	320..363	CDD:270506	9/55 (16%)
		zf-C3HC4_3	447..492	CDD:290631	10/47 (21%)
Birc6	NP_001164067.1	BIR	290..363	CDD:237989	31/76 (41%)
		DUF3643	3472..3624	CDD:289152
		UBCc	4605..4743	CDD:238117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810