DRSC/TRiP Functional Genomics Resources

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Protein Alignment Diap2 and Nlrc4

DIOPT Version :9

Sequence 1:NP_477127.1 Gene:Diap2 / 36748 FlyBaseID:FBgn0015247 Length:498 Species:Drosophila melanogaster
Sequence 2:NP_001296361.1 Gene:Nlrc4 / 298784 RGDID:1309831 Length:1023 Species:Rattus norvegicus


Alignment Length:248 Identity:55/248 - (22%)
Similarity:85/248 - (34%) Gaps:93/248 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   267 FEHAKWSPKC----QFVLL-AKGPAYVSEVLATTAANASSQPATAPAPTLQADVLMDEAPAKEAL 326
            |:..|:.|.|    .||.| ..|.|.||:  ..|..|:|......|:..:         |:: |:
  Rat   596 FDF
FKYLPNCVSALDFVKLDFYGRATVSQ--DKTGENSSGVHTEGPSTYI---------PSR-AV 648

  Fly   327 ALGIDGGVVRNAIQRKLLSSGCAFSTLDELLHD--------------IFDDAGAGAALEVREPPE 377
            :|..      |.:|:        |.||:..|.|              ||..|   :.|::     
  Rat   649 SLFF------NWMQK--------FKTLEVTLRDISKLNKQDIKYLGKIFSSA---SNLKL----- 691

  Fly   378 PSAPFIEPCQATTSKAASVPIPVAD----SIPAKPQAAEAVANISKITDEIQKMSV--------- 429
                :|:.|.|...:.:||.....:    .:.|.|...|....|:.:|| :|.:|:         
  Rat   692 ----YIKRCAAVAGRLSSVLRTCKNIHSLMVEASPLTTEDEQYITSVTD-LQNLSIHDLHTQRLP 751

  Fly   430 ---ATPNGNL-------------------SLEEENRQLKDARLCKVCLDEEVG 460
               |...|||                   ||.|..|.||..||..:....::|
  Rat   752 GGLADSLGNLKNLLKLILDDIRLNEEDAKSLAEGLRNLKKMRLLHLTRLSDMG 804

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Diap2NP_477127.1 BIR 12..78 CDD:237989
BIR 112..181 CDD:197595
BIR 213..281 CDD:237989 6/17 (35%)
UBA_IAPs 320..363 CDD:270506 12/56 (21%)
zf-C3HC4_3 447..492 CDD:290631 3/14 (21%)
Nlrc4NP_001296361.1 CARD 1..86 CDD:279013
Nucleotide-binding domain (NBD). /evidence=ECO:0000250 95..298
P-loop_NTPase 163..316 CDD:304359
Winged-helix domain (WHD). /evidence=ECO:0000250 356..463
LRR 1 578..598 1/1 (100%)
LRR 2 655..678 6/30 (20%)
leucine-rich repeat 663..688 CDD:275381 5/27 (19%)
leucine-rich repeat 689..712 CDD:275381 6/31 (19%)
leucine-rich repeat 713..736 CDD:275381 4/22 (18%)
LRR 3 734..757 5/23 (22%)
LRR_RI 736..1008 CDD:238064 16/70 (23%)
leucine-rich repeat 737..788 CDD:275381 9/50 (18%)
LRR 4 761..784 3/22 (14%)
LRR 5 786..811 6/19 (32%)
leucine-rich repeat 789..820 CDD:275381 5/16 (31%)
leucine-rich repeat 821..845 CDD:275381
LRR 6 823..846
LRR 7 847..869
LRR 8 877..901
LRR 9 910..932
LRR 10 935..962
LRR 11 964..984
LRR 12 998..1020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166334412
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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