DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Diap2 and bir1

DIOPT Version :9

Sequence 1:	NP_477127.1	Gene:	Diap2 / 36748	FlyBaseID:	FBgn0015247	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_587866.3	Gene:	bir1 / 2538875	PomBaseID:	SPCC962.02c	Length:	997	Species:	Schizosaccharomyces pombe

Alignment Length:	369	Identity:	90/369 - (24%)
Similarity:	136/369 - (36%)	Gaps:	77/369 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 ANRLVTF--KDWPNPNITPQALAKAGFYY--------LNRLDHVKCVWCNGVIAKWEKNDNAFEE 168
            :.||.||  |.||....||:.||..||||        ..|||:|.|..|......||.:|:..:|
pombe    23 SKRLDTFQKKKWPRAKPTPETLATVGFYYNPISESNSEERLDNVTCYMCTKSFYDWEDDDDPLKE 87

  Fly   169 HKRFFPQCPRVQMGPLIEFATGKNLDELGIQPTTLPLRPKYACVDARLRTFTD--WPISN----- 226
            |....|.||...:      .:.||      .|...|  ...|....|.:||.|  ||.:|
pombe    88 HITHSPSCPWAYI------LSSKN------NPNQNP--QAAALTKCREQTFVDKVWPYTNRPDYH 138

  Fly   227 IQPASALAQAGLYYQKIG---DQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYV 288
            .:| |.:|.:|..|....   |...|.:|:|.|..|:.:|:|:.||.:....|.| ...|.|..:
pombe   139 CEP-SVMAASGFVYNPTADAKDAAHCLYCDINLHDWEPDDDPYTEHKRRRADCVF-FTWKDPNSL 201

  Fly   289 S--EVLATTAANASSQPATAPAPTLQADVLMDEAPAKEALALGIDGGVVRNAIQRKLLSSGCAFS 351
            |  ::...:.:|...:..|.....|......|...:.:.|......   :|.:..:.|:.....:
pombe   202 SPTKLSFLSTSNIDPEDLTEDNSILPVSPTRDSTKSHKTLNFSPSR---KNNLNARPLTMSLYTN 263

  Fly   352 TLDELLHDIFDDAGAGAALEVREPPEPSAPFI--EPCQATTSKAASVPI---PVA---------- 401
            |.:|           ..:...|.|..|:.|.:  .|.:...|...|.|.   ||.
pombe   264 TSEE-----------KDSQPTRAPQSPTKPVLLTAPRRKNKSPKKSKPAVFKPVKPIFSDEDEDD 317

  Fly   402 DSIPAKPQAAEAVANISKITDEIQKMSVATPN--GNLSLEEENR 443
            |.:.|....::.:.|.|        |.||..|  ..:.|:|:.:
pombe   318 DDLTASQPFSKGICNDS--------MQVAKKNFTEEIPLKEDEK 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Diap2	NP_477127.1	BIR	12..78	CDD:237989
		BIR	112..181	CDD:197595	29/76 (38%)
		BIR	213..281	CDD:237989	24/77 (31%)
		UBA_IAPs	320..363	CDD:270506	5/42 (12%)
		zf-C3HC4_3	447..492	CDD:290631
bir1	NP_587866.3	BIR	21..100	CDD:197595	29/76 (38%)
bir1	NP_587866.3	BIR	120..194	CDD:279047	24/75 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46995
orthoMCL	1	0.900	-	-		OOG6_100552
Panther	1	1.100	-	-	O	PTHR10044
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R141
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.800