Protein Alignment Diap2 and bir-2

DIOPT Version :10

• Sequence 1: NP_477127.1
• Gene: Diap2 / 36748
• FlyBaseID: FBgn0015247
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_506362.1
• Gene: bir-2 / 179841
• WormBaseID: WBGene00000250
• Length: 308
• Species: Caenorhabditis elegans
• Alignment Length: 567
• Identity: 109/567 - (19%)
• Similarity: 180/567 - (31%)
• Gaps: 191/567 - (33%)

  Fly   693 TEDHIFGEEFDKIREQGSQGSLKTPPEVPRHSSLPLIQTAASAAGNMA------ALSTVQQAAPF 751
            ::|:|...|.:||....|: |||              :.|..|:..:.      ......|.||.
 Worm    18 SKDYIEVSEDEKITRTRSR-SLK--------------KKAIKASNKLTHSLRKRGKRVADQYAPI 67

  Fly   752 SPENIPDTLGDDEDDPFSSAPFS---LPVRTD---------KSKSFKLASRKVIVI--------- 795
            ..|::.|...:...:.|..|..|   ||.|.|         |::.|.|  .|.:.:
 Worm    68 VIEDVRDEEEEKAVNVFRKALVSLDLLPPRHDDYHTMLRFLKARRFDL--EKTVQMWEEMLKWRK 130

  Fly   796 DGGFSTQLTEHV----------------GAKLDKDPLWTSRFNATNP-----AAVLETHLDYLKA 839
            :.|..|.:.:.|                |...:..|::..|....:|     ...||..|.|...
 Worm   131 ENGVDTIIQDFVYDEYEEVQQYYPHGYHGVDREGRPVYIERLGKIDPGKLMKVTTLERFLRYHVQ 195

  Fly   840 GADCILTNTYQA----------------SIEG--YMDFLDLNED--------------ESLK--- 869
            |.:...:..:.|                .:.|  :|.|..|.:|              |:|.
 Worm   196 GFEKTFSEKFPACSIAAKRHINSSTTIIDVHGVSWMSFRKLAQDLVMRMQKIDGDNYPETLNQMY 260

  Fly   870 LIRA--SVELARRARTRYLAEKLENKSHKIPWVVGSIGPYGAHL------HDGSEYTGA---YAE 923
            :|.|  ..:|.......:|..|..:|.|    |:|:  .|.:||      .:..|:.|.   .|.
 Worm   261 IINAGNGFKLVWNTVKGFLDPKTTSKIH----VLGN--KYRSHLLEIIDPSELPEFLGGNCKCAH 319

  Fly   924 HVPANRLQK--WHRPRINAIVEAGVDALAIETIPCRMEAEALLDLLS-ADHPTVRFWISFQCRDG 985
            .....|..|  |:.|.|..:|.:. ||:........:|...:..|.| ..|...    .....||
 Worm   320 EGGCMRFNKGPWNDPEIMKLVRSR-DAMYKPKEMGLLENGEVAKLFSLRQHVNT----DMSSPDG 379

  Fly   986 ASLAHGENFAETVLGLWNRARQLAN-------------------PNLLAI---------GVNCVN 1022
            ..:...|:..|     .::..||:|                   ||.||:         .|....
 Worm   380 GHVRERESHPE-----HDKRAQLSNQAEAVGVGRMEQSDSTSPLPNNLAVERSLTTSLQKVASFL 439

  Fly  1023 PQHVLPLLRSVHELLQ--QRAAGTPPESERIPLI-------------VYPNSGEHWDAAASCWRG 1072
            .:.:|.||.|:..:.:  .|.....||::..|.:             |:|           ||..
 Worm   440 ARFILQLLGSLCLMFRILGRLVNKQPENQLRPELSVSVSQQQVPPPQVHP-----------CWLR 493

  Fly  1073 AENLTPLETYL-------PQWVEMGVKFVGGCCRTNARDIKRIKKAV 1112
            .:||..:.|.|       ||..|..::......::..:|:::.|||:
 Worm   494 LQNLETMVTVLCDKPSSIPQEKEDILRDSLDRIKSIEQDLQKTKKAL 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Diap2	NP_477127.1	BIR	12..78	CDD:237989
		BIR	112..181	CDD:197595
		BIR	213..281	CDD:237989
		UBA_IAPs	320..363	CDD:270506
		RING-HC_BIRC2_3_7	442..498	CDD:438373
bir-2	NP_506362.1	BIR	23..99	CDD:197595	20/90 (22%)
		BIR	166..242	CDD:197595	14/75 (19%)