Protein Alignment Diap2 and Xiap

DIOPT Version :10

• Sequence 1: NP_477127.1
• Gene: Diap2 / 36748
• FlyBaseID: FBgn0015247
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: XP_011249278.1
• Gene: Xiap / 11798
• MGIID: 107572
• Length: 548
• Species: Mus musculus
• Alignment Length: 540
• Identity: 164/540 - (30%)
• Similarity: 243/540 - (45%)
• Gaps: 125/540 - (23%)

  Fly    12 RLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSPICSMV 76
            ||.||..:|.::||||..|...||..||.....:|..||..||||:|||....||||.||.|..:
Mouse    81 RLKTFANFPSSSPVSASTLARAGFLYTGEGDTVQCFSCHAAIDRWQYGDSAVGRHRRISPNCRFI 145

  Fly    77 --------LAPNHCGNVPRSQ-ESDN-EGN---------------------SVVD--------SP 102
                    .|.:....:...| :|:| .||                     .|||        :|
Mouse   146 NGFYFENGAAQSTNPGIQNGQYKSENCVGNRNPFAPDRPPETHADYLLRTGQVVDISDTIYPRNP 210

  Fly   103 ESCSCPDLLLEANRLVTFKDWPN-PNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAF 166
            ..||      |..||.:|::||: .::||:.||.||.||....|.|:|..|.|.:..||..|.|:
Mouse   211 AMCS------EEARLKSFQNWPDYAHLTPRELASAGLYYTGADDQVQCFCCGGKLKNWEPCDRAW 269

  Fly   167 EEHKRFFPQCPRVQMGPLIEFATGKNLD---ELGI-------QPTTLPLRPKYACVDARLRTFTD 221
            .||:|.||.|         .|..|:|::   |.|:       ..|..|..|..|..:||:.||..
Mouse   270 SEHRRHFPNC---------FFVLGRNVNVRSESGVSSDRNFPNSTNSPRNPAMAEYEARIVTFGT 325

  Fly   222 WPISNIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPA 286
            | .|::. ...||:||.|....||:|:||||..||..|:..::||.:||||.|.|:::|..||..
Mouse   326 W-TSSVN-KEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLDEKGQE 388

  Fly   287 YVSEVLATTAANASSQPATAPAPTLQA---DVLMDEAPAKEALALGIDGGVVRNAIQRKLLSSGC 348
            |::.:..|.:...|........|:|..   |.:......:||:.:|.....::..::.|:.:||.
Mouse   389 YINNIHLTHSLEESLGRTAEKTPSLTKKIDDTIFQNPMVQEAIRMGFSFKDIKKTMEEKIQTSGS 453

  Fly   349 AFSTLDELLHDIFDDAGAGAALEVREPPEPSAPFIEPCQATTSKAASVPIPVADSIPAKPQAAEA 413
            ::.:|:.|                                           :||.:.|:....|
Mouse   454 SYLSLEVL-------------------------------------------IADLVSAQKDNTE- 474

  Fly   414 VANISKITDEIQKMSVATPNGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHLATCNQCAPS 478
                    ||..:.|:   ..::|.||:.|:|::.:|||:|:|..:.:||:|||||.||.|||.:
Mouse   475 --------DESSQTSL---QKDISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEA 528

  Fly   479 VANCPMCRADIKGFVRTFLS 498
            |..||||...|....:.|:|
Mouse   529 VDKCPMCYTVITFKQKIFMS 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Diap2	NP_477127.1	BIR	12..78	CDD:237989	31/73 (42%)
		BIR	112..181	CDD:197595	29/69 (42%)
		BIR	213..281	CDD:237989	29/67 (43%)
		UBA_IAPs	320..363	CDD:270506	8/42 (19%)
		RING-HC_BIRC2_3_7	442..498	CDD:438373	26/55 (47%)
Xiap	XP_011249278.1	BIR	80..147	CDD:237989	31/65 (48%)
		BIR	214..284	CDD:197595	31/84 (37%)
		BIR	316..382	CDD:197595	29/67 (43%)
		UBA_BIRC4_8	421..470	CDD:270578	11/91 (12%)
		RING-HC_BIRC4_8	485..548	CDD:438374	29/62 (47%)