DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Diap2 and birc7

DIOPT Version :9

Sequence 1:	NP_477127.1	Gene:	Diap2 / 36748	FlyBaseID:	FBgn0015247	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001106593.2	Gene:	birc7 / 100127811	XenbaseID:	XB-GENE-5914029	Length:	385	Species:	Xenopus tropicalis

Alignment Length:	416	Identity:	144/416 - (34%)
Similarity:	212/416 - (50%)	Gaps:	74/416 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 PDLLLEANRLVTFKDWPNP--NITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHK 170
            |::..||.|..:|:.||:.  .::|..||::|||||...|.|:|..|.||:..||..|....||:
Frog    19 PNMRSEAERQRSFRAWPHTCRTVSPAELARSGFYYLGPGDRVQCFSCGGVLRSWEPGDRPDTEHR 83

  Fly   171 RFFPQCP--RVQMGPL--IEFATGKNLDEL-GIQP--TTLPLRPKYACVDARLRTFTDWP-ISNI 227
            :|||.||  :|:.||.  .:...|:.|.:| |.:|  |..|:.|:.|....||.:|:.|| .:|.
Frog    84 KFFPSCPFLQVRRGPPGGTDSVDGQILGQLSGEEPDRTWEPVCPQMAGEGDRLGSFSTWPRYANG 148

  Fly   228 QPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVSEV- 291
            .| ..||.||.:|....|.|:||||:.|||:|::.|:||.|||||.|.|.|:|..||.|::..|
Frog   149 DP-QQLAGAGFFYTGHRDHVKCFHCDGGLRNWEQGDDPWTEHAKWFPMCDFLLQVKGEAFIRSVQ 212

  Fly   292 -------------LATTAANASSQPATAP-APTLQADVLMDEAPAKEALALGIDGGVVRNAIQRK 342
                         :.:...:..|.|.:.| .|.|...|      |:.||.:|.....|.:.:..:
Frog   213 ESFFSSPETSPESVGSYEGSPVSSPGSPPVCPFLSTSV------AQGALQMGFKRNRVSSLMINR 271

  Fly   343 LLSSGCAFSTLDELLHDIFDDAGAGAALEVREPPEPSAPFIEPCQATTSKAASVPIPVADSIPAK 407
            .:.:|..:.::.||:.|:..      |.|:......|.|     :|.|.:....|       |.:
Frog   272 FILTGSCYGSVSELVTDLIQ------AEEIHGTESVSVP-----RAPTQRERPEP-------PKE 318

  Fly   408 PQAAEAVANISKITDEIQKMSVATPNGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHLATC 472
            |                     |.|   ||.||:.||||:.|:||||:|.:|.:||:|||||..|
Frog   319 P---------------------APP---LSTEEQLRQLKEERMCKVCMDNDVSMVFVPCGHLVVC 359

  Fly   473 NQCAPSVANCPMCRADIKGFVRTFLS 498
            .:|||::.:||:|||.|:|.||.|:|
Frog   360 TECAPNLRHCPICRAAIRGSVRAFMS 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Diap2	NP_477127.1	BIR	12..78	CDD:237989
		BIR	112..181	CDD:197595	31/72 (43%)
		BIR	213..281	CDD:237989	33/68 (49%)
		UBA_IAPs	320..363	CDD:270506	9/42 (21%)
		zf-C3HC4_3	447..492	CDD:290631	24/44 (55%)
birc7	NP_001106593.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8680
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340284at2759
OrthoFinder	1	1.000	-	-		FOG0000512
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10044
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R141
SonicParanoid	1	1.000	-	-		X559
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.050