DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdg and SLC6A5

DIOPT Version :9

Sequence 1:	NP_611064.2	Gene:	bdg / 36747	FlyBaseID:	FBgn0034049	Length:	1331	Species:	Drosophila melanogaster
Sequence 2:	NP_004202.4	Gene:	SLC6A5 / 9152	HGNCID:	11051	Length:	797	Species:	Homo sapiens

Alignment Length:	898	Identity:	191/898 - (21%)
Similarity:	327/898 - (36%)	Gaps:	245/898 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 EDDIPTLLVELPPR--RDAEM-RRCFSQGDCQASVA--PTVGSQMLTEAHIFDNLLQTNARASSE 371
            |.::|......|||  |.|.. .:.|...|.:|..|  |.|||..|:         ...|:|:|.
Human    37 EQELPAAAAPPPPRVPRSASTGAQTFQSADARACEAERPGVGSCKLS---------SPRAQAASA 92

  Fly   372 EPRPRQYGRRLEGPPTPVRPLILAQSRPQSAPTRVQMREPQLQDTPTHPIMSTCSELSSARSSRM 436
            ..|..:..:..:..|.|      ..|.|.:|   :..:.|.|                     |.
Human    93 ALRDLREAQGAQASPPP------GSSGPGNA---LHCKIPFL---------------------RG 127

  Fly   437 PSPVSLPSDSS-SSGSSSAEHDQEP-----DPVQTTTMCSASSTTPLEPLHQLQLLLRE------ 489
            |.     .|:: |.|..:.|.:..|     :..|:|.:.:....|.:.|.....:..:|
Human   128 PE-----GDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQEDEQGDE 187

  Fly   490 -KCGFNSQWPHAGSRTLALIGCTLGVFNMCRFAVLTI-NFGGNFLLQFLLLSVIFGIPLLWLQMC 552
             |...|  |.......|:::|..:|:.|:.||..|.. |.||.||:.:|::..:.|:|:.:|::.
Human   188 NKARGN--WSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVS 250

  Fly   553 LGAKIRAGPVSMWKISPICAGVGIALVMQQCFLALYSTVSLAWILVYLRDVFPTAARSG---YRW 614
            ||.....||||:||..|...|.|||:::....:|:|..|.:.:.|.||...|.:....|   ..|
Human   251 LGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPW 315

  Fly   615 QE-------------------------------MAFPYRYDASNATGNLTQTVA----EYFNVVV 644
            ..                               .|:| .....|.|....:|..    |||...|
Human   316 NTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYP-NVTMVNFTSQANKTFVSGSEEYFKYFV 379

  Fly   645 LQRLHLANHPDASGIRFHVNDR-QLAFYLALIWAAVFLILCKGLKSLGKLAYIIYTLPLVALAVV 708
            |:        .::||.:....| .||..|.|.|..|:..|.||:|:.||:.|...|.|.|.|.::
Human   380 LK--------ISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVIL 436

  Fly   709 TAKFV----------YVVDPSRIQNIFAASDFDDFLVNSNSWTAATQETFLT----WGLLGASVI 759
            ..:.|          |.:.|..           :.|.::..|..|..:.|.:    ||  |...:
Human   437 LIRGVTLPGAGAGIWYFITPKW-----------EKLTDATVWKDAATQIFFSLSAAWG--GLITL 488

  Fly   760 AITSRSHTNANKAALRRDAILLVLFTLIGLGLMALLALCCAQILWQHGYVYVPGSFENPDCYTSI 824
            :..::.|.|.     .||. |:|..|.....:.|             |:|              |
Human   489 SSYNKFHNNC-----YRDT-LIVTCTNSATSIFA-------------GFV--------------I 520

  Fly   825 YSLQSNTNPYLLSYPRSLIPHYSSFIGETYRRNRTMIHVESGFQ---ALRFISEIFPAVLSLASD 886
            :|:                      ||  :..|...:::|:...   .:.|:  ::|..|:..
Human   521 FSV----------------------IG--FMANERKVNIENVADQGPGIAFV--VYPEALTRL-- 557

  Fly   887 SISWVWAAVAFATFAGFGLAQLCVMWKPISSALGNSTSSVLLS---------CVTGLLLSIPFAT 942
            .:|..||.:.|......||..:....:.|.:::.:.....|.:         |:...::..|..|
Human   558 PLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMIT 622

  Fly   943 EMGISILYYVDFLLGGSWFIPIIWTAQIFGVFLIRGRPYNGDDLVNDLRLCGSMSAFLALSWNVL 1007
            :.||.:...|| ....|:.:.||...::.|:..:.|..          |.|..:...:....|:.
Human   623 QGGIYMFQLVD-TYAASYALVIIAIFELVGISYVYGLQ----------RFCEDIEMMIGFQPNIF 676

  Fly  1008 LPI--GLITLSVVDYKASLSNQFYYWRGKSYFTY----WSRKMGSLIQIGVLLVIPVTAIIQIYR 1066
            ..:  ..:|.:::.:....|  ||.|...:|.:|    ||..:|.|:....::.||:..:|::
Human   677 WKVCWAFVTPTILTFILCFS--FYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKM-- 737

  Fly  1067 YLAHGPPDILERIQLLYRP-PEEGEEPRRPSARQTASQSRRN---ALGQTTEG 1115
            :||  |...:||::|:..| |:.|     |...|...:..:|   .||.::.|
Human   738 HLA--PGRFIERLKLVCSPQPDWG-----PFLAQHRGERYKNMIDPLGTSSLG 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	116/540 (21%)
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..118		25/98 (26%)
SLC6A5	NP_004202.4	SLC6sbd_GlyT2	191..787	CDD:271389	151/700 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900