Protein Alignment bdg and slc6a3

DIOPT Version :10

• Sequence 1: NP_611064.2
• Gene: bdg / 36747
• FlyBaseID: FBgn0034049
• Length: 1331
• Species: Drosophila melanogaster
• Sequence 2: NP_571830.1
• Gene: slc6a3 / 80787
• ZFINID: ZDB-GENE-010316-1
• Length: 629
• Species: Danio rerio
• Alignment Length: 778
• Identity: 188/778 - (24%)
• Similarity: 290/778 - (37%)
• Gaps: 232/778 - (29%)

  Fly   394 LAQSRPQSAPTRVQMREPQLQDTPTHPIMSTCSELSSARSSRMPSPVSLPSD-----SSSS---- 449
            :.:.||....||          |.||..||:.|..|||...|....|.:...     :|||
Zfish     3 MLRGRPAVTHTR----------TRTHTHMSSVSGSSSAAGPREVELVLVKEQNGVQFTSSSLRNP 57

  Fly   450 GSSSAEHDQEPDPVQTTTMCSASSTTPLEPLHQLQLLLREKCGFNSQWPHAGSRTLALIGCTLGV 514
            |:.|..|                :.|...|..|.:....:|..|          .|::||..:.:
Zfish    58 GAHSHTH----------------THTHTHPSGQQRETWGKKIDF----------LLSVIGFAVDL 96

  Fly   515 FNMCRFAVLTI-NFGGNFLLQFLLLSVIFGIPLLWLQMCLGAKIRAGPVSMWKISPICAGVGIAL 578
            .|:.||..|.. |.||.||:.:||..||.|:||.::::.||...|.|...:|||.||..|||..:
Zfish    97 ANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQYNREGAAGVWKICPIFKGVGFTV 161

  Fly   579 VMQQCFLALYSTVSLAWILVYLRDVFPTAARSGYRWQEMAFPYRY--------DASNATGNL--- 632
            ::...::..|..|.:||.|.||...|     ||      ..|:.:        :.|:....|
Zfish   162 ILISLYVGSYYNVIIAWALFYLFSSF-----SG------ELPWIHCNNTWNSPNCSDPNATLLND 215

  Fly   633 ---TQTVAEYFNVVVLQRLHLANHPDASGIRFHVNDR-----QLAFYLALIWAAVFLILCKGLKS 689
               |....|||...|| .:|     ::|||    :|.     ||...||::...::..|.||:|:
Zfish   216 TYKTTPALEYFERGVL-HVH-----ESSGI----DDLGAPRWQLTACLAVVIVVLYFSLWKGVKT 270

  Fly   690 LGKLAYIIYTLPLVALAVVTAKFVYVVDPSRIQNIFAASDFDDF-LVNSNSW-TAATQETFLTWG 752
            .||:.:|..|:|.|.|.|:..:.|.:  |..|..|.|....|.. |.::..| .||||
Zfish   271 SGKVVWITATMPYVVLTVLLLRGVTL--PGAIDGIKAYLSVDFLRLYDAQVWIEAATQ------- 326

  Fly   753 LLGASVIAITSRSHTNANKAALRRDAILLVLFTLIGLGLMALLALCCAQILWQHGYVYVPGSFEN 817
                                         :.|:| |:|...|:|.        ..|    ..|.|
Zfish   327 -----------------------------ICFSL-GVGFGVLIAF--------SSY----NKFSN 349

  Fly   818 PDCY------TSIYSLQSNTNPYLLSYPRSLIPHYSSFIG-ETYRRNRTMIHVESGFQALRFISE 875
             :||      :||.||.|..:.:::          .||:| .:.:.|..:..|.:....|.||
Zfish   350 -NCYRDAIITSSINSLTSFFSGFVI----------FSFLGYMSQKHNVALDKVATDGPGLVFI-- 401

  Fly   876 IFP-AVLSLASDSISWVWAAVAFATFAGFGLAQLCVMWKPISSALGNSTSSV------------- 926
            |:| |:.:|...|   |||.:.|......|          |.||:|...|.:
Zfish   402 IYPEAIATLPGSS---VWAVIFFIMLLTLG----------IDSAMGGMESVITGLIDEFKFLHKH 453

  Fly   927 -----LLSCVTGLLLSIPFATEMGISILYYVDFLLGGSWFIPIIWTAQIFGVFL-------IRGR 979
                 |...|:..|:|:...|..||.:...:|....|        |:.:|||.:       ..|.
Zfish   454 RELFTLFIVVSTFLISLICVTNGGIYVFTLLDHFAAG--------TSILFGVLIEAIGIAWFYGV 510

  Fly   980 PYNGDDLVNDL--------RLCGSMSAFLALSWNVLLPIGLITLSVVDYKASLSNQFYYWRGKSY 1036
            ....||:...:        |||          |..:.|..|:.:.||.: |:.:...|   |..|
Zfish   511 DRFSDDIEEMIGQRPGLYWRLC----------WKFVSPCFLLFMVVVSF-ATFNPPKY---GSYY 561

  Fly  1037 FTYWSRKMGSLIQIGVLLVIPVTAIIQIYRYLAHGPPDILERIQLLYRPPEEGEEPRRPSARQ 1099
            |..|:..:|..:.|..::::|:.|   .|::.:. |....:::.....|..:.....|...||
Zfish   562 FPTWATMVGWCLSISSMIMVPLYA---FYKFCSL-PGSFCDKLAYAITPETDHHLVERGEVRQ 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	135/529 (26%)
slc6a3	NP_571830.1	SLC6sbd_DAT1	76..623	CDD:212083	164/679 (24%)