DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bdg and Slc6a1

DIOPT Version :9

Sequence 1:	NP_611064.2	Gene:	bdg / 36747	FlyBaseID:	FBgn0034049	Length:	1331	Species:	Drosophila melanogaster
Sequence 2:	NP_077347.1	Gene:	Slc6a1 / 79212	RGDID:	620533	Length:	599	Species:	Rattus norvegicus

Alignment Length:	722	Identity:	168/722 - (23%)
Similarity:	291/722 - (40%)	Gaps:	187/722 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 LPSDSS--SSGSSSAEHDQEPDPVQTTTMCSASSTTPLEPLHQLQLLLREKCG---FNSQWPHAG 501
            :.:|:|  :.|..|.|..:.|          .:|..|    ..|.:.:::|.|   ....|....
  Rat     1 MATDNSKVADGQISTEVSEAP----------VASDKP----KTLVVKVQKKAGDLPDRDTWKGRF 51

  Fly   502 SRTLALIGCTLGVFNMCRFAVLT-INFGGNFLLQFLLLSVIFGIPLLWLQMCLGAKIRAGPVSMW 565
            ...::.:|..:|:.|:.||..|. .|.||.||:.:.|..:..|:||..|:..||.....|.:.:|
  Rat    52 DFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVW 116

  Fly   566 KISPICAGVGIALVMQQCFLALYSTVSLAWILVYLRDVFPTAARSGYRWQEMAFPYRYDA--SN- 627
            |::|:..|||:|..:...:|.:|..|.::|.:.||.:.|.|.    ..|::...|:..|.  ||
  Rat   117 KLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTT----LPWKQCDNPWNTDRCFSNY 177

  Fly   628 ---ATGNLTQTVAEYFNVVVLQRLH-LANHPDASG-IRFHVNDRQLAFYLALIWAAVFLILCKGL 687
               .|.|:|..|.|::.    :.:| :.:..|..| ||:     .||..||:.|..|:..:.||:
  Rat   178 SLVNTTNMTSAVVEFWE----RNMHQMTDGLDKPGQIRW-----PLAITLAIAWVLVYFCIWKGV 233

  Fly   688 KSLGKLAYIIYTLPLVALAVVTAKFVYVVDPSRIQNI--FAASDFDDFLVNSNSWTAATQETFLT 750
            ...||:.|...|.|.:.|.::.  |..|..|...:.|  :...:|.. |.:|..|..|..:.|.:
  Rat   234 GWTGKVVYFSATYPYIMLIILF--FRGVTLPGAKEGILFYITPNFRK-LSDSEVWLDAATQIFFS 295

  Fly   751 WGLLGASVIAITSRS--HTNANKAALRRDAILLVLFTLIGLGLMALLALCCAQILWQHGYVYVPG 813
            :||...|:||:.|.:  |.|     :.||:|:                :||..
  Rat   296 YGLGLGSLIALGSYNSFHNN-----VYRDSII----------------VCCIN------------ 327

  Fly   814 SFENPDCYTSIYSLQSNTNPYLLSYPRSLIPHYSSFIGETYRRNRTMIHVESGFQALRFISEIFP 878
                 .| ||:::      .:::......:.|.:         .|::..|.:....|.|::  :|
  Rat   328 -----SC-TSMFA------GFVIFSIVGFMAHVT---------KRSIADVAASGPGLAFLA--YP 369

  Fly   879 -AVLSLASDSISWVWAAVAFATFAGFGL-AQLCVMWKPISSALGNSTSSVLLS---------CVT 932
             ||..|   .||.:||.:.|:.....|: :|.|.: :...:||.:....:|.:         |:.
  Rat   370 EAVTQL---PISPLWAILFFSMLLMLGIDSQFCTV-EGFITALVDEYPRLLRNRRELFIAAVCIV 430

  Fly   933 GLLLSIPFATEMGI--------------SILYYVDF-LLGGSWFIPIIWTAQIFGVFLIRGRPYN 982
            ..|:.:...|:.||              |:|:.|.| .:..|||         :||    .|.|:
  Rat   431 SYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWF---------YGV----NRFYD 482

  Fly   983 GDDLVNDLRLCGSMSA-FLALSWNVLLPI---GLITLSVVDYKASLSNQFYYWRGKSYFTYWSRK 1043
                 |...:.||... :..|.|:...||   |:...|.|....       ...|...|..|.:.
  Rat   483 -----NIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTP-------LTMGSYVFPKWGQG 535

  Fly  1044 MGSLIQIGVLLVIPVTAIIQIYRYLAH------GPPDILERIQLLYRP------PEEGEEPRRPS 1096
            :|.|:.:..:::||        .|:|:      |  .:.:|:|::.:|      ||.|  |.:|.
  Rat   536 VGWLMALSSMVLIP--------GYMAYMFLTLKG--SLKQRLQVMIQPSEDIVRPENG--PEQPQ 588

  Fly  1097 ARQTASQ 1103
            |..:||:
  Rat   589 AGSSASK 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	123/513 (24%)
Slc6a1	NP_077347.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		6/31 (19%)
		SLC6sbd_GAT1	2..599	CDD:212075	168/721 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..599		8/21 (38%)
		PDZ-binding	597..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900