Protein Alignment bdg and SLC6A12

DIOPT Version :10

• Sequence 1: NP_611064.2
• Gene: bdg / 36747
• FlyBaseID: FBgn0034049
• Length: 1331
• Species: Drosophila melanogaster
• Sequence 2: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Alignment Length: 671
• Identity: 153/671 - (22%)
• Similarity: 247/671 - (36%)
• Gaps: 155/671 - (23%)

  Fly   496 QWPHAGSRTLALIGCTLGVFNMCRFAVLTI-NFGGNFLLQFLLLSVIFGIPLLWLQMCLGAKIRA 559
            ||.:.....|::.|..:|:.|:.||..|.. |.||.|.:.:.:...:.|||:.:|::.||.....
Human    38 QWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQ 102

  Fly   560 GPVSMW-KISPICAGVGIALVMQQCFLALYSTVSLAWILVYLRDVF----PTAARSGYRWQEMAF 619
            |.|:.| ||.|:..|:|:|.|:.:.:|.:|..:.|||.|.||...|    |....:.: |..
Human   103 GSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNF-WNT--- 163

  Fly   620 PYRYDASNATG--------NLTQTVAEYFNVVVL---QRLHLANHPDASGIRFHVNDRQLAFYLA 673
            .:..|..|.:|        |.|..|.|::...||   ..:|     |...:|:     :||..|.
Human   164 EHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIH-----DLGSLRW-----ELALCLL 218

  Fly   674 LIWAAVFLILCKGLKSLGKLAYIIYTLPLVALAVVTAKFVYVVDPSRIQNIFAASDFDDF-LVNS 737
            |.|...:..:.||:||.||:.|...|.|.:.|.::..:.|.:  |...|.|......|.| |.:.
Human   219 LAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTL--PGAYQGIIYYLKPDLFRLKDP 281

  Fly   738 NSWTAATQETFLTWGLLGASVIAITS--RSHTNANKAALRRDAILLVLFTLIGLGLMALLALCCA 800
            ..|..|..:.|.::.:....:.|:.|  :.|.|..|     |.|                |||
Human   282 QVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYK-----DCI----------------ALC-- 323

  Fly   801 QILWQHGYVYVPGSFENPDCYTSIYSLQSNTNPYLLSYPRSLIPHYSSFIGETYRRNRTMIHVES 865
                   ::....||.......||....|....         :|     |.|.         .||
Human   324 -------FLNSATSFVAGFVVFSILGFMSQEQG---------VP-----ISEV---------AES 358

  Fly   866 GFQALRFISEIFPAVLSLASDSISWVWAAVAF--ATFAGFGLAQLCV---------MWKPISSAL 919
            | ..|.||:  ||..:::.  .:|.:|:.:.|  ..|.|.....:||         |:.......
Human   359 G-PGLAFIA--FPKAVTMM--PLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKS 418

  Fly   920 GNSTSSVLLSCVTGLLLSIPFATEMGISILYYVDF-------LLGGSWF--IPIIWTAQIFGV-- 973
            |.....:|...|...|:.:...||.|:.|....|:       ||..|.|  :.|.|   ::|.
Human   419 GRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISW---VYGADR 480

  Fly   974 ------FLIRGRPYNGDDLVNDLRLCGSMSAFLALSWNVLLP---IGLITLSVVDYKASLSNQFY 1029
                  .:|..||:                ..:.:||..|.|   :.....|:..|.....|..|
Human   481 FYDNIEDMIGYRPW----------------PLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVY 529

  Fly  1030 YWRGKSYFTYWSRKMGSLIQIGVLLVIPVTAIIQIYRYLAHGPPDILERIQLLYRPPEEGEEPRR 1094
                  .:..|...:|..:.:..::.:|:..:|.:.:  ..||  ..:|::.|..|.....:|::
Human   530 ------VYPPWGYSIGWFLALSSMVCVPLFVVITLLK--TRGP--FRKRLRQLITPDSSLPQPKQ 584

  Fly  1095 PSARQTASQSRRNALGQTTEG 1115
            ..... .|..|......|.||
Human   585 HPCLD-GSAGRNFGPSPTREG 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	125/522 (24%)
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	146/639 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		6/30 (20%)